Russian Chemical Bulletin

, Volume 64, Issue 7, pp 1633–1639 | Cite as

Formation and pharmacological activity of silicon—chitosan-containing glycerohydrogels obtained by biomimetic mineralization

  • E. V. Shadrina
  • O. N. Malinkina
  • T. G. Khonina
  • A. B. Shipovskaya
  • V. I. Fomina
  • E. Yu. Larchenko
  • N. A. Popova
  • I. G. Zyryanova
  • L. P. Larionov
Full Articles


The biomimetic sol—gel synthesis of silicon—chitosan-containing glycerohydrogels was carried out using silicon tetraglycerolate as a precursor. It was found that chitosan accelerates gel formation in weakly acidic media. In more acidic media, the kinetics of the process changes according to the curve with a maximum, which can be attributed to different mechanisms of silanol condensation before and after the isoelectric point. The investigated silicon—chitosan-containing glycerohydrogels exhibit antibacterial, anti-inflammatory, and wound healing activity. The synthesized hybrid glycerohydrogels are promising materials for biomedical applications.

Key words

silicon—chitosan-containing glycerohydrogels sol—gel synthesis biomimetic mineralization pharmacological activity 


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • E. V. Shadrina
    • 1
  • O. N. Malinkina
    • 2
  • T. G. Khonina
    • 1
  • A. B. Shipovskaya
    • 2
  • V. I. Fomina
    • 2
  • E. Yu. Larchenko
    • 1
  • N. A. Popova
    • 3
  • I. G. Zyryanova
    • 3
  • L. P. Larionov
    • 3
  1. 1.I. Ya. Postovsky Institute of Organic SynthesisUral Branch of the Russian Academy of SciencesEkaterinburgRussian Federation
  2. 2.N. G. Chernyshevsky Saratov State UniversitySaratovRussian Federation
  3. 3.Ural State Medical UniversityEkaterinburgRussian Federation

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