Advertisement

Russian Chemical Bulletin

, Volume 64, Issue 7, pp 1633–1639 | Cite as

Formation and pharmacological activity of silicon—chitosan-containing glycerohydrogels obtained by biomimetic mineralization

  • E. V. Shadrina
  • O. N. Malinkina
  • T. G. Khonina
  • A. B. Shipovskaya
  • V. I. Fomina
  • E. Yu. Larchenko
  • N. A. Popova
  • I. G. Zyryanova
  • L. P. Larionov
Full Articles

Abstract

The biomimetic sol—gel synthesis of silicon—chitosan-containing glycerohydrogels was carried out using silicon tetraglycerolate as a precursor. It was found that chitosan accelerates gel formation in weakly acidic media. In more acidic media, the kinetics of the process changes according to the curve with a maximum, which can be attributed to different mechanisms of silanol condensation before and after the isoelectric point. The investigated silicon—chitosan-containing glycerohydrogels exhibit antibacterial, anti-inflammatory, and wound healing activity. The synthesized hybrid glycerohydrogels are promising materials for biomedical applications.

Key words

silicon—chitosan-containing glycerohydrogels sol—gel synthesis biomimetic mineralization pharmacological activity 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    H. Ehrlich, D. Janussen, P. Simon, V. Bazhenov, N. Shapkin, C. Erler, M. Mertig, R. Born, S. Heinemann, T. Hanke, H. Worch, J. Vournakis, J. Nanomaterials, 2008, doi:10.1155/2008/670235.Google Scholar
  2. 2.
    M. Sumper, E. Brunner, ChemBioChem, 2008, 9, 1187.CrossRefGoogle Scholar
  3. 3.
    K. Spinde, M. Kammer, K. Freyer, H. Ehrlich, J. N. Vournakis, E. Brunner, Chem. Mater., 2011, 23, 2973.CrossRefGoogle Scholar
  4. 4.
    M. Wysokowki, T. Behm, R. Born, V. V. Bazhenov, H. Meißner, G. Richter, K. Szwarc-Rzepka, A. Makarova, D. Vyalikh, P. Schupp, T. Jesionowski, H. Ehrlich, Mater. Sci. Eng. C, 2013, 33, 3935.CrossRefGoogle Scholar
  5. 5.
    T. Coradin, R. Brayner, C. Gautier, M. Hemadi1, P. J. Lopez, J. Livage, Editorial Universitaria S.A., 2007, 419.Google Scholar
  6. 6.
    Y. A. Shchipunov, T. Yu. Karpenko, Langmuir, 2004, 20, 3882.CrossRefGoogle Scholar
  7. 7.
    Y. A. Shchipunov, T. Yu. Karpenko, A. V. Krekoten, I. V. Postnova, J. Colloid Interface Sci., 2005, 287, 373.CrossRefGoogle Scholar
  8. 8.
    V. Pedroni, P. C. Schulz, M. E. Gschaider de Ferreira, M. A. Morini, Colloid Polym. Sci., 2000, 278, 964.CrossRefGoogle Scholar
  9. 9.
    K. Madhumathi, P. T. S. Kumar, K. C. Kavya, T. Furuike, H. Tamura, S. V. Nair, R. Jayakumar, Int. J. Biol. Macromol., 2009, 45, 289.CrossRefGoogle Scholar
  10. 10.
    G. J. Copello, A. M. Mebert, M. Raineri, M. P. Pesentia, L. E. Diaz, J. Hazard. Mater., 2011, 186, 932.CrossRefGoogle Scholar
  11. 11.
    Khitozan [Chitosan], Eds K. G. Skryabin, S. N. Mikhailov, and V. P. Varlamov, Center "Bioinzheneriya" of the Russian Academy of Sciences, Moscow, 2013, 591 pp. (in Russian).Google Scholar
  12. 12.
    M. N. V. Ravi Kumar, R. A. A. Muzzarelli, C. Muzzarelli, A. J. Domb, Chem. Rev., 2004, 104, 6017.CrossRefGoogle Scholar
  13. 13.
    I. Gill, A. Ballesteros, J. Am. Chem. Soc., 1998, 120, 8587.CrossRefGoogle Scholar
  14. 14.
    T. G. Khonina, O. N. Chupakhin, L. P. Larionov, T. G. Boyakovskaya, A. L. Suvorov, E. V. Shadrina, Pharm. Chem. J. (Engl. Transl.), 2008, 11, No. 42, 609 [Khim.-Farm. Zh., 2008, 11, 5].CrossRefGoogle Scholar
  15. 15.
    T. G. Khonina, E. V. Shadrina, A. A. Boiko, O. N. Chupakhin, L. P. Larionov, A. A. Volkov, V. D. Burda, Russ. Chem. Bull. (Int. Ed.), 2010, 59, 75 [Izv. Akad. Nauk, Ser. Khim., 2010, 76].CrossRefGoogle Scholar
  16. 16.
    T. G. Khonina, A. P. Safronov, E. V. Shadrina, M. V. Ivanenko, A. I. Suvorova, O. N. Chupakhin, J. Colloid Interface Sci., 2012, 365, 81.CrossRefGoogle Scholar
  17. 17.
    E. Yu. Larchenko, T. G. Khonina, O. N. Chupakhin, L. P. Larionov, Perspektivnye Materialy [Perspective Materials], 2011, 13, 978 (in Russian).Google Scholar
  18. 18.
    E. Y. Larchenko, E. V. Shadrina, T. G. Khonina, O. N. Chupakhin, Mendeleev Commun., 2014, 24, 201.CrossRefGoogle Scholar
  19. 19.
    E. Yu. Larchenko, T. G. Khonina, E. V. Shadrina, A. V. Pestov, O. N. Chupakhin, N. V. Men´shutina, A. E. Lebedev, D. D. Lovskaya, L. P. Larionov, S. A. Chigvintsev, Russ. Chem. Bull. (Int. Ed.), 2014, 63, 1225–1231 [Izv. Akad. Nauk, Ser. Khim., 2014, 1225].CrossRefGoogle Scholar
  20. 20.
    Yu. Shchipunov, N. Ivanova, V. Silant´ev, Green Chem., 2009, 11, 1758.CrossRefGoogle Scholar
  21. 21.
    Yu. A. Shchipunov, N. A. Ivanova, S. A. Sarin, Mendeleev Commun., 2009, 19, 149.CrossRefGoogle Scholar
  22. 22.
    E. Brunner, K. Lutz, M. Sumper, Phys. Chem. Chem. Phys., 2004, 6, 854.CrossRefGoogle Scholar
  23. 23.
    O. Helmecke, A. Hirsch, P. Behrens, H. Menzel, J. Colloid Interface Sci., 2008, 321, 44.CrossRefGoogle Scholar
  24. 24.
    D. Brandhuber, V. Torma, C. Raab, H. Peterlik, A. Kulak, N. Hüsing, Mater. Chem., 2005, 17, 4262.CrossRefGoogle Scholar
  25. 25.
    A. C. Pierre, Introduction to Sol—Gel Processing, Kluwer, Boston, 1998, 394 pp.CrossRefGoogle Scholar
  26. 26.
    J. Livage, M. Henry, C. Sanchez, Prog. Solid State Chem., 1988, 18, 259.CrossRefGoogle Scholar
  27. 27.
    O. N. Chupakhin, A. N. Bondarev, I. N. Shtan´ko, T. G. Khonina, E. V. Shadrina, E. A. Bogdanova, L. P. Larionov, Russ. Chem. Bull. (Int. Ed.), 2014, 63, 1219–1224 [Izv. Akad. Nauk, Ser. Khim., 2014, 1219].CrossRefGoogle Scholar
  28. 28.
    R. Muzzarelli, Mar. Drugs, 2010, 8, 292.CrossRefGoogle Scholar
  29. 29.
    A. B. Shipovskaya, D. A. Rudenko, V. I. Fomina, N. V. Ostrovsky, Eur. J. Natural History, 2012, 6, 7.Google Scholar
  30. 30.
    I. Younes, S. Sellimi, M. Rinaudo, K. Jellouli, M. Nasri, Int. J. Food Microbiology, 2014, 185, 57.CrossRefGoogle Scholar
  31. 31.
    A. I. Gamzazade, V. M. Slimak, A. M. Sklar, E. V. Shtikova, S. V. Pavlova, S. V. Rogojin, Acta Polymerica, 1985, 36, No. 8, 420.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • E. V. Shadrina
    • 1
  • O. N. Malinkina
    • 2
  • T. G. Khonina
    • 1
  • A. B. Shipovskaya
    • 2
  • V. I. Fomina
    • 2
  • E. Yu. Larchenko
    • 1
  • N. A. Popova
    • 3
  • I. G. Zyryanova
    • 3
  • L. P. Larionov
    • 3
  1. 1.I. Ya. Postovsky Institute of Organic SynthesisUral Branch of the Russian Academy of SciencesEkaterinburgRussian Federation
  2. 2.N. G. Chernyshevsky Saratov State UniversitySaratovRussian Federation
  3. 3.Ural State Medical UniversityEkaterinburgRussian Federation

Personalised recommendations