Russian Chemical Bulletin

, Volume 64, Issue 7, pp 1547–1554 | Cite as

Enzymatic mechanisms of biological magnetic sensitivity: nuclear spin effects

  • U. G. Letuta
  • V. L. Berdinskii


Intracellular enzymatic reactions involving ion-radical states are shown to act as a universal mechanism of magnetically sensitive living organisms. Weak magnetic fields can affect the rate of intracellular enzymatic reactions. The main magnetically sensitive stage is the singlet-triplet conversion of ion-radical pairs in the active sites of enzymes induced by Zeeman and hyperfine interactions of electron and nuclear spins. The participation of a nuclear spin in the ion-radical process results in a strong dependence of the enzymatic reaction rate in weak magnetic fields comparable with the magnetic field of the Earth.

Key words

magnetic field enzymatic ion-radical reactions hyperfine interaction nuclear spin biological magnetic sensitivity 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    A. L. Buchachenko, Russ. Chem. Rev., 2014, 83, 1.CrossRefGoogle Scholar
  2. 2.
    W. Wiltschko, R. Wiltschko, J. Comp. Physiol. A, 2005, 191, 675.CrossRefGoogle Scholar
  3. 3.
    C. T. Rodgersa, P. Hore, PNAS, 2009, 106, 353.CrossRefGoogle Scholar
  4. 4.
    K. J. Lohmann, Nature, 2010, 464, 1140.CrossRefGoogle Scholar
  5. 5.
    S. Johnsen, K. J. Lohmann, Nature Rev. Neurosci., 2005, 6, 703.CrossRefGoogle Scholar
  6. 6.
    S. Johnsen, K. J. Lohmann, Phys. Today, 2008, 10, 29.CrossRefGoogle Scholar
  7. 7.
    K. Fijaikowski, P. Nawrotek, M. Struk, M. Kordas, R. Rakoczy, J. Magnetics, 2013, 18, 289.CrossRefGoogle Scholar
  8. 8.
    P. Nawrotek, K. Fijaikowski, M. Struk, M. Kordas, R. Rakoczy, Electromagnetic Biol. Med., 2014, 33, 29.CrossRefGoogle Scholar
  9. 9.
    J. Filipièa, B. Kraigher, B. Tepu´, V. Kokol, I. Mandic-Mule, Bioresource Technol., 2012, 120, 225.CrossRefGoogle Scholar
  10. 10.
    A. L. Buchachenko, R. Z. Sagdeev, K. M. Salikhov, Magnitnye i spinovye effekty v khimicheskikh reaktsiyakh [Magnetic and Spin Effects in Chemical Reactions], Nauka, Novosibirsk, 1978, 296 pp. (in Russian).Google Scholar
  11. 11.
    U. E. Steiner, T. Ulrich, Chem Rev., 1989, 89, 51.CrossRefGoogle Scholar
  12. 12.
    R. Banerjee, Chem. Rev., 2003, 103, 2083.CrossRefGoogle Scholar
  13. 13.
    T. Toraya, Chem. Rev., 2003, 103, 2095.CrossRefGoogle Scholar
  14. 14.
    M. Fontecave, S. Ollagnier-de-Choudens, E. Mulliez, Chem. Rev., 2003, 103, 2149.CrossRefGoogle Scholar
  15. 15.
    A. L. Buchachenko, D. A. Kuznetsov, S. E. Arkhangelsky, M. A. Orlova, A. A. Markaryan, Cell Biochem. Biophys., 2005, 43, 243.CrossRefGoogle Scholar
  16. 16.
    A. L. Buchachenko, Magnetic Isotope Effect in Chemistry and Biochemistry, Nova Science Publishers, New York, 2009, 141 pp.Google Scholar
  17. 17.
    A. L. Buchachenko, D. A. Kuznetsov, N. N. Breslavskaya, Chem. Rev., 2012, 112, 2042.CrossRefGoogle Scholar
  18. 18.
    A. L. Buchachenko, A. P. Orlov, D. A. Kuznetsov, N. N. Breslavskaya, Nucleic Acids Res., 2013, 41, 8300.CrossRefGoogle Scholar
  19. 19.
    A. L. Buchachenko, A. P. Orlov, D. A. Kuznetsov, N. N. Breslavskaya, Chem. Phys. Lett., 2013, 586, 138.CrossRefGoogle Scholar
  20. 20.
    A. L. Buchachenko, D. A. Kuznetsov, J. Am. Chem. Soc., 2008, 130, 2868.CrossRefGoogle Scholar
  21. 21.
    O.-M. H. Richter, B. Ludwig, Rev. Physiol. Biochem. Pharmacol., 2003, 147, 47.Google Scholar
  22. 22.
    U. G. Shevchenko, E. I. Avdeeva, V. L. Berdinsky, Russ. J. Phys. Chem. B (Engl. Transl.), 2012, 6, No. 4, 531 [Khim. Fiz., 2012, 31, No. 7, 62].Google Scholar
  23. 23.
    U. G. Letuta, E. I. Avdeeva, V. L. Berdinskii, Russ. Chem. Bull. (Int. Ed.), 2014, 63, 1102 [Izv. Akad. Nauk, Ser. Khim., 2014, 1102].CrossRefGoogle Scholar
  24. 24.
    A. L. Buchachenko, N. Lukzen, B. Pedersen, Chem. Phys. Lett., 2007, 434, 139.CrossRefGoogle Scholar
  25. 25.
    B. Pedersena, M. Mojazaa, N. N. Lukzen, Chem. Phys. Lett., 2010, 496, 212.CrossRefGoogle Scholar
  26. 26.
    U. G. Shevchenko (Letuta), V. L. Berdinsky, Russ. J. Phys. Chem. B (Engl. Transl.), 2011, 5, No. 3, 519 [Khim. Fiz., 2011, 30, No. 6, 78].CrossRefGoogle Scholar
  27. 27.
    A. L. Buchachenko, D. A. Kuznetsov, V. L. Berdinskii, Biofizika [Biophysics], 2005, 80, 16 (in Russian).Google Scholar
  28. 28.
    G. Pileio, Progress Nucl. Magn. Res. Spectr., 2010, 56, 217.CrossRefGoogle Scholar
  29. 29.
    M. H. Levitt, Annu. Rev. Phys. Chem., 2012, 63, 89.CrossRefGoogle Scholar
  30. 30.
    A. Carrington, A. D. McLachlan, Introduction to Magnetic Resonance with Applications to Chemistry and Chemical Physics, Happer and Row Publishers, New York—Evanston—London, 1967.Google Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Orenburg State UniversityOrenburgRussian Federation
  2. 2.Institute of Cellular and Intercellular SymbiosisUral Branch of the Russian Academy of SciencesOrenburgRussian Federation

Personalised recommendations