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Membrane protective properties of carboxy derivatives based on 2,6-diisobornyl-4-methylphenol

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Abstract

Toxicity, antioxidant activity, and membrane protective properties were studied on mammalian red blood cells for carboxy derivatives and esters of 2,6-diisobornyl-4-methylphenol in comparison with both diastereomers (meso-form and racemate) of this terpenophenol. The studies showed that all the synthesized compounds posses an antioxidant activity, however, the cytotoxicity of derivatives with a free carboxy group might be an obstacle to the use of these compounds in pharmacology. The most promising compound is methyl 4-hydroxy-3,5-diisobornylbenzoate distinguished by a low toxicity and high antioxidant and membrane protective activity, which is comparable to that of 2,6-diisobornyl-4-methylphenol.

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Authors and Affiliations

  1. Institute of Chemistry, Komi Scientific Center of the Ural Branch of the Russian Academy of Sciences, 48 ul. Pervomaiskaya, 167982, Syktyvkar, Russian Federation

    E. V. Buravlev, I. Yu. Chukicheva, O. V. Sukrusheva & A. V. Kutchin

  2. Institute of Biology, Komi Scientific Center of the Ural Branch of the Russian Academy of Sciences, 28 ul. Kommunisticheskaya, 167982, Syktyvkar, Russian Federation

    O. G. Shevchenko

Authors
  1. E. V. Buravlev
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  2. I. Yu. Chukicheva
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  3. O. V. Sukrusheva
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  4. O. G. Shevchenko
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  5. A. V. Kutchin
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Corresponding author

Correspondence to I. Yu. Chukicheva.

Additional information

On the occasion of the 100th anniversary of the birth of Academician N. K. Kochetkov (1915–2005).

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 6, pp. 1406–1412, June, 2015.

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Buravlev, E.V., Chukicheva, I.Y., Sukrusheva, O.V. et al. Membrane protective properties of carboxy derivatives based on 2,6-diisobornyl-4-methylphenol. Russ Chem Bull 64, 1406–1412 (2015). https://doi.org/10.1007/s11172-015-1024-1

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  • DOI: https://doi.org/10.1007/s11172-015-1024-1

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