Membrane protective properties of carboxy derivatives based on 2,6-diisobornyl-4-methylphenol
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Toxicity, antioxidant activity, and membrane protective properties were studied on mammalian red blood cells for carboxy derivatives and esters of 2,6-diisobornyl-4-methylphenol in comparison with both diastereomers (meso-form and racemate) of this terpenophenol. The studies showed that all the synthesized compounds posses an antioxidant activity, however, the cytotoxicity of derivatives with a free carboxy group might be an obstacle to the use of these compounds in pharmacology. The most promising compound is methyl 4-hydroxy-3,5-diisobornylbenzoate distinguished by a low toxicity and high antioxidant and membrane protective activity, which is comparable to that of 2,6-diisobornyl-4-methylphenol.
Key words2,6-diisobornyl-4-methylphenol carboxy derivatives esters diastereomers antioxidants membrane protective properties red blood cells oxidative hemolysis
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