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Russian Chemical Bulletin

, Volume 64, Issue 6, pp 1406–1412 | Cite as

Membrane protective properties of carboxy derivatives based on 2,6-diisobornyl-4-methylphenol

  • E. V. Buravlev
  • I. Yu. Chukicheva
  • O. V. Sukrusheva
  • O. G. Shevchenko
  • A. V. Kutchin
Full Articles

Abstract

Toxicity, antioxidant activity, and membrane protective properties were studied on mammalian red blood cells for carboxy derivatives and esters of 2,6-diisobornyl-4-methylphenol in comparison with both diastereomers (meso-form and racemate) of this terpenophenol. The studies showed that all the synthesized compounds posses an antioxidant activity, however, the cytotoxicity of derivatives with a free carboxy group might be an obstacle to the use of these compounds in pharmacology. The most promising compound is methyl 4-hydroxy-3,5-diisobornylbenzoate distinguished by a low toxicity and high antioxidant and membrane protective activity, which is comparable to that of 2,6-diisobornyl-4-methylphenol.

Key words

2,6-diisobornyl-4-methylphenol carboxy derivatives esters diastereomers antioxidants membrane protective properties red blood cells oxidative hemolysis 

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • E. V. Buravlev
    • 1
  • I. Yu. Chukicheva
    • 1
  • O. V. Sukrusheva
    • 1
  • O. G. Shevchenko
    • 2
  • A. V. Kutchin
    • 1
  1. 1.Institute of ChemistryKomi Scientific Center of the Ural Branch of the Russian Academy of SciencesSyktyvkarRussian Federation
  2. 2.Institute of BiologyKomi Scientific Center of the Ural Branch of the Russian Academy of SciencesSyktyvkarRussian Federation

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