Membrane protective properties of carboxy derivatives based on 2,6-diisobornyl-4-methylphenol
- 25 Downloads
Toxicity, antioxidant activity, and membrane protective properties were studied on mammalian red blood cells for carboxy derivatives and esters of 2,6-diisobornyl-4-methylphenol in comparison with both diastereomers (meso-form and racemate) of this terpenophenol. The studies showed that all the synthesized compounds posses an antioxidant activity, however, the cytotoxicity of derivatives with a free carboxy group might be an obstacle to the use of these compounds in pharmacology. The most promising compound is methyl 4-hydroxy-3,5-diisobornylbenzoate distinguished by a low toxicity and high antioxidant and membrane protective activity, which is comparable to that of 2,6-diisobornyl-4-methylphenol.
Key words2,6-diisobornyl-4-methylphenol carboxy derivatives esters diastereomers antioxidants membrane protective properties red blood cells oxidative hemolysis
Unable to display preview. Download preview PDF.
- 1.O. I. Kiselev, Khimiopreparaty i khimioterapiya grippa [Chemotherapy Agents and Chemotherapy of Influenza], Rostok, St.-Petersburg, 2012, 272 pp. (in Russian).Google Scholar
- 3.M. D. Mashkovskii, Lekarstvennye sredstva [Medicines], 14th ed., Novaya Volna, Moscow, 2000, V. 1, 540 pp. (in Russian).Google Scholar
- 4.A. T. Soldatenkov, N. M. Kolyadina, I. V. Shendrik, Osnovy organicheskoi khimii lekarstvennykh veshchestv [Principles of Organic Chemistry of Medicinal Agents], Mir, BINOM. Laboratoriya Znanii, Moscow, 2007, 191 pp. (in Russian).Google Scholar