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Russian Chemical Bulletin

, Volume 64, Issue 3, pp 689–694 | Cite as

Synthesis of 6-thienyl-substituted 2-amino-3-cyanopyridines

  • E. V. Verbitskiy
  • E. M. Cheprakova
  • M. G. Pervova
  • G. G. Danagulyan
  • G. L. Rusinov
  • O. N. Chupakhin
  • V. N. Charushin
Full Articles

Abstract

An efficient method for the synthesis of 6-thienyl-substituted 2-amino-3-cyanopyridines by the ring transformation in the corresponding pyrimidines was developed. Further modification of the pyridines obtained under conditions of a room temperature aerobic Suzuki reaction in the presence of trans-bis(dicyclohexylamine)palladium(II) acetate as a catalyst was studied

Key words

pyrimidines pyridines transformations of heterocycle Suzuki cross-coupling trans-bis(dicyclohexylamine)palladium(II) acetate 

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • E. V. Verbitskiy
    • 1
    • 2
  • E. M. Cheprakova
    • 1
    • 2
  • M. G. Pervova
    • 1
  • G. G. Danagulyan
    • 3
    • 4
  • G. L. Rusinov
    • 1
    • 2
  • O. N. Chupakhin
    • 1
    • 2
  • V. N. Charushin
    • 1
    • 2
  1. 1.I. Ya. Postovsky Institute of Organic SynthesisUral Branch of the Russian Academy of SciencesEkaterinburgRussian Federation
  2. 2.Ural Federal University named after the first president of Russia B. N. EltsinEkaterinburgRussian Federation
  3. 3.Russian-Armenian (Slavonic) UniversityYerevanRepublic of Armenia
  4. 4.Scientific-Technological Center of Organic and Pharmaceutical ChemistryNational Academy of Sciences of the Republic of ArmeniaYerevanRepublic of Armenia

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