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Russian Chemical Bulletin

, Volume 63, Issue 10, pp 2375–2382 | Cite as

Design of a hybrid nanostructure based on fullerene C60 and biologically active substance for modeling physiological properties of compounds

  • R. A. Kotel’nikova
  • V. V. Grigoriev
  • A. V. Smolina
  • I. I. Faingold
  • D. V. Mishchenko
  • G. I. Van’kin
  • V. L. Zamoiskii
  • D. A. Poletaeva
  • N. A. Markova
  • V. S. Romanova
  • A. I. Kotel’nikov
  • G. Aliev
  • S. O. Bachurin
Full Articles

Abstract

The effects of cognitive-stimulating substance BD-2 of the γ-carboline family and a hybrid compound based on fullerene C60 and attached BD-2 on various aspects of the behavior of animals were studied. The synthesized hybrid fullerene compound (HFC) has no side psychostimulating effect characteristic of BD-2 but fully retains the properties of a cognitive-stimulating agent. The design of hybrid compounds based on fullerene C60 and pharmacologically active groups can be one of the ways for optimizing therapeutically promising compounds.

Key words

water-soluble fullerene derivatives antioxidant activity glutamate AMPA receptors cognitive stimulators 

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • R. A. Kotel’nikova
    • 1
  • V. V. Grigoriev
    • 2
  • A. V. Smolina
    • 1
  • I. I. Faingold
    • 1
  • D. V. Mishchenko
    • 1
  • G. I. Van’kin
    • 2
  • V. L. Zamoiskii
    • 2
  • D. A. Poletaeva
    • 1
  • N. A. Markova
    • 2
  • V. S. Romanova
    • 3
  • A. I. Kotel’nikov
    • 1
  • G. Aliev
    • 4
  • S. O. Bachurin
    • 2
  1. 1.Institute of Problems of Chemical Physics of the Russian Academy of SciencesChernogolovkaRussian Federation
  2. 2.Institute of Physiologically Active Compounds of the Russian Academy of SciencesChernogolovkaRussian Federation
  3. 3.A. N. Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of SciencesMoscowRussian Federation
  4. 4.School of Health Science and Healthcare AdministrationUniversity of AtlantaAtlantaUSA

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