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Russian Chemical Bulletin

, Volume 63, Issue 9, pp 2081–2086 | Cite as

Synthesis and structure of potentially biologically active N-(silylmethyl)tetrahydropyrimidin-2-ones

  • N. F. Lazareva
  • I. M. Lazarev
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Abstract

A transsilylation of 1,3-bis(trimethylsilyl)tetrahydropyrimidin-2-one with (chloromethyl)-chlorosilanes ClCH2SiMenCl3–n (n = 0, 2) gave the corresponding 1,3-bis[(chlorosilyl)-methyl]tetrahydropyrimidin-2-ones. New Si-containing tetrahydropyrimidin-2-ones were synthesized by the exchange reactions at the Si—Cl and Si—N bonds of these compounds. The structures of all the synthesized compounds were confirmed by multinuclear NMR spectroscopy. Virtual screening using the PASS program showed that these compounds can exhibit certain types of biological activity with 40—94% probability.

Keywords

1,3-bis(trimethylsilyl)tetrahydropyrimidin-2-one 1,3-bis(silylmethyl)tetrahydropyrimidin-2-ones transsilylation transetherification potential biological activity 

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.A. E. Favorsky Irkutsk Institute of ChemistrySiberian Branch of the Russian Academy of SciencesIrkutskRussian Federation

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