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Russian Chemical Bulletin

, Volume 63, Issue 7, pp 1619–1623 | Cite as

Synthesis of water-soluble chitosan derivatives and their use for the stabilization of liposomal suspensions

  • V. S. Ponomarev
  • K. V. Kozhikhova
  • I. D. Shulepov
  • M. I. Tokareva
  • M. N. Ivantsova
  • M. A. Mironov
Article

Abstract

A method was developed for chitosan modification using the multicomponent Ugi reaction. The obtained products are highly soluble in water in a wide range of pH 2–11. They were used for the stabilization of liposomal suspensions based on phosphatidylcholin, which retained colloidal stability for three months upon the addition of modified chitosan in a ratio of 1: 5.

Key words

multicomponent reactions isocyanides chitosan Ugi reaction liposomes 

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • V. S. Ponomarev
    • 1
  • K. V. Kozhikhova
    • 1
  • I. D. Shulepov
    • 1
  • M. I. Tokareva
    • 1
  • M. N. Ivantsova
    • 1
  • M. A. Mironov
    • 1
  1. 1.Ural Federal University named after the first President of Russia B. N. YeltsinEkaterinburgRussian Federation

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