Synthesis of 4-oxothiazolidine-2,5-diylidenes containing thioamide group based on dithiomalonamides
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An approach to the synthesis of 2-(4-oxo-3-arylthiazolidine-2,5-diylidene)-N-arylethanethioamide derivatives from N,N′-diarylmalonodithioamides includes two steps: preparation of thiazoles using the Hantzsch reaction with subsequent modification of the active methylene group by the Knoevenagel condensation or enamination using dimethylformamide dimethyl acetal (DMF-DMA). Configuration and isomerization of the double bonds in 4-oxothiazolidine-2,5-diylidenes were confirmed by 1H NMR and X-ray diffraction analysis and discussed.
Key wordsthiazolidin-4-one 4-oxothiazole thioamide isatin rhodacyanine DMF-DMA malonodithioamide
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