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Russian Chemical Bulletin

, Volume 63, Issue 6, pp 1330–1336 | Cite as

Synthesis of 4-oxothiazolidine-2,5-diylidenes containing thioamide group based on dithiomalonamides

  • K. L. Obydennov
  • N. A. Golovko
  • M. F. Kosterina
  • T. A. Pospelova
  • P. A. Slepukhin
  • Yu. Yu. Morzherin
Full Articles

Abstract

An approach to the synthesis of 2-(4-oxo-3-arylthiazolidine-2,5-diylidene)-N-arylethanethioamide derivatives from N,N′-diarylmalonodithioamides includes two steps: preparation of thiazoles using the Hantzsch reaction with subsequent modification of the active methylene group by the Knoevenagel condensation or enamination using dimethylformamide dimethyl acetal (DMF-DMA). Configuration and isomerization of the double bonds in 4-oxothiazolidine-2,5-diylidenes were confirmed by 1H NMR and X-ray diffraction analysis and discussed.

Key words

thiazolidin-4-one 4-oxothiazole thioamide isatin rhodacyanine DMF-DMA malonodithioamide 

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • K. L. Obydennov
    • 1
  • N. A. Golovko
    • 1
  • M. F. Kosterina
    • 1
  • T. A. Pospelova
    • 1
  • P. A. Slepukhin
    • 2
  • Yu. Yu. Morzherin
    • 1
  1. 1.Ural Federal University named after the First President of Russia B. N. YeltsinEkaterinburgRussian Federation
  2. 2.I. Ya. Postovsky Institute of Organic SynthesisUral Branch of the Russian Academy of SciencesEkaterinburgRussian Federation

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