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Russian Chemical Bulletin

, Volume 63, Issue 5, pp 1036–1047 | Cite as

Sonodynamic therapy of cancer. A comprehensive experimental study

  • A. L. Nikolaev
  • A. V. Gopin
  • V. E. Bozhevolnov
  • S. E. Mazina
  • A. V. Severin
  • V. N. Rudin
  • N. V. Andronova
  • H. M. Treschalina
  • O. L. Kaliya
  • L. I. Solovyeva
  • E. A. Lukyanets
Reviews

Abstract

Sonodynamic therapy in combination with antitumor drugs and sonosensitizers (theraphthal and its derivatives) was studied in preclinical testing against malignant tumors. The use of this therapy scheme enhances the destructive effect of ultrasound on tumors, promotes no metastasis, and make therapeutic drugs more bioavailable. The scheme was recommended for clinical use. A solid-phase sonosensitization mechanism was proposed. A possible system of laboratory and in vitro testing for selection of efficient sonosensitizers was outlined.

Key words

ultrasound cavitation malignant tumors solid-phase sonosensitization sonodynamic therapy nanoparticles theraphthal hydroxyapatite 

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • A. L. Nikolaev
    • 1
  • A. V. Gopin
    • 1
  • V. E. Bozhevolnov
    • 1
  • S. E. Mazina
    • 1
  • A. V. Severin
    • 1
  • V. N. Rudin
    • 1
  • N. V. Andronova
    • 2
  • H. M. Treschalina
    • 2
  • O. L. Kaliya
    • 3
  • L. I. Solovyeva
    • 3
  • E. A. Lukyanets
    • 3
  1. 1.Department of ChemistryM. V. Lomonosov Moscow State UniversityMoscowRussian Federation
  2. 2.N. N. Blokhin Russian Cancer Research CenterRussian Academy of Medical SciencesMoscowRussian Federation
  3. 3.Research Institute of Intermediates and DyesMoscowRussian Federation

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