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Russian Chemical Bulletin

, Volume 62, Issue 9, pp 2037–2040 | Cite as

Reaction of 5β,6β-epoxy-16α,17α-cyclohexapregnane with methylmagnesium iodide

  • I. S. Levina
  • L. E. Kulikova
  • V. V. Kachala
  • L. L. Khemchyan
Full Articles
  • 51 Downloads

Abstract

On treatment with methylmagnesium iodide, 3β-acetoxy-5β,6β-epoxy-16α,17α-cyclo-hexapregnan-20-one undergoes 3-O-deacetylation along with the opening of the 5β,6β-epoxide ring to form 5α-methyl-6β-hydroxy steroid and the 6α-methyl-6β-hydroxy isomer, the 20-keto group remaining intact.

Key words

steroids epoxidation 16α,17α-cyclohexapregnanes methylmagnesium iodide 

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • I. S. Levina
    • 1
  • L. E. Kulikova
    • 1
  • V. V. Kachala
    • 1
  • L. L. Khemchyan
    • 1
  1. 1.N. D. Zelinsky Institute of Organic ChemistryRussian Academy of SciencesMoscowRussian Federation

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