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Crystal structures of pyridinemonocarboxylic acid peroxosolvates

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Abstract

The crystal structures of new peroxosolvates of the following pyridinemonocarboxylic acids were studied: picolinic 2-C5H4NCOOH·H2O2 (1), nicotinic 3-C5H4NCOOH·H2O2 (2), and isonicotinic 4-C5H4NCOOH·2H2O2 (3). In these compounds, the acids exist exclusively as zwitterions, as opposed to non-solvated crystals. In compounds 1–3, the hydrogen peroxide molecules form two donor hydrogen bonds and, in some cases, one additional acceptor hydrogen bond. Peroxosolvate 2 can be considered as a novel drug formulation of vitamin B3.

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Authors and Affiliations

  1. N. S. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, 31 Leninsky prosp., 119991, Moscow, Russian Federation

    A. G. Medvedev, A. A. Mikhailov, P. V. Prikhodchenko, T. A. Tripol’skaya & A. V. Churakov

  2. Casali Institute of Applied Chemistry, Chemistry Institute, Hebrew University of Jerusalem, 91904, Jerusalem, Israel

    O. Lev

Authors
  1. A. G. Medvedev
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  2. A. A. Mikhailov
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  3. P. V. Prikhodchenko
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  4. T. A. Tripol’skaya
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  5. O. Lev
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  6. A. V. Churakov
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Correspondence to A. V. Churakov.

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Dedicated to the memory of the Corresponding Member of the Russian Academy of Sciences M. Yu. Antipin (1951–2013).

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1871–1876, August, 2013.

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Medvedev, A.G., Mikhailov, A.A., Prikhodchenko, P.V. et al. Crystal structures of pyridinemonocarboxylic acid peroxosolvates. Russ Chem Bull 62, 1871–1876 (2013). https://doi.org/10.1007/s11172-013-0269-9

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  • DOI: https://doi.org/10.1007/s11172-013-0269-9

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