Russian Chemical Bulletin

, Volume 62, Issue 8, pp 1871–1876 | Cite as

Crystal structures of pyridinemonocarboxylic acid peroxosolvates

  • A. G. Medvedev
  • A. A. Mikhailov
  • P. V. Prikhodchenko
  • T. A. Tripol’skaya
  • O. Lev
  • A. V. Churakov
Full Articles


The crystal structures of new peroxosolvates of the following pyridinemonocarboxylic acids were studied: picolinic 2-C5H4NCOOH·H2O2 (1), nicotinic 3-C5H4NCOOH·H2O2 (2), and isonicotinic 4-C5H4NCOOH·2H2O2 (3). In these compounds, the acids exist exclusively as zwitterions, as opposed to non-solvated crystals. In compounds 13, the hydrogen peroxide molecules form two donor hydrogen bonds and, in some cases, one additional acceptor hydrogen bond. Peroxosolvate 2 can be considered as a novel drug formulation of vitamin B3.

Key words

hydrogen peroxide peroxosolvates pyridinemonocarboxylic acids X-ray diffraction crystal packing hydrogen bonding drug formulation 


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • A. G. Medvedev
    • 1
  • A. A. Mikhailov
    • 1
  • P. V. Prikhodchenko
    • 1
  • T. A. Tripol’skaya
    • 1
  • O. Lev
    • 2
  • A. V. Churakov
    • 1
  1. 1.N. S. Kurnakov Institute of General and Inorganic ChemistryRussian Academy of SciencesMoscowRussian Federation
  2. 2.Casali Institute of Applied Chemistry, Chemistry InstituteHebrew University of JerusalemJerusalemIsrael

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