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Russian Chemical Bulletin

, Volume 61, Issue 11, pp 2163–2171 | Cite as

Synthesis of pharmacologically active hydrogels based on combined silicon and titanium polyolates

  • M. V. Ivanenko
  • T. G. Khonina
  • O. N. Chupakhin
  • L. P. Larionov
  • R. R. Sakhautdinova
  • A. P. Safronov
Full Article

Abstract

The target synthesis of new biologically active hydrogels based on combined silicon and titanium polyolates was carried out. The optimum conditions for hydrogel formation and their composition were determined. The type of hydrogels and mechanisms of gelation depend on the nature of polyols: gels based on combined silicon and titanium polyethylene glycolates are polymeric and formed via the polycondensation mechanism, whereas gels based on combined silicon and titanium glycerolates are colloidal and formed via the coagulation-condensation mechanism. The combined hydrogels based on silicon dimethyl glycerolates and titanium tetraglycerolate exhibit enhanced transcutaneous, wound healing, and regenerating activity.

Key words

silicon and titanium polyolates silicon-titanium hydrogels wound healing, regenerating, and transcutaneous activity 

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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • M. V. Ivanenko
    • 1
  • T. G. Khonina
    • 1
  • O. N. Chupakhin
    • 1
    • 2
  • L. P. Larionov
    • 3
  • R. R. Sakhautdinova
    • 3
  • A. P. Safronov
    • 2
    • 4
  1. 1.I. Ya. Postovsky Institute of Organic SynthesisUral Branch of the Russian Academy of SciencesEkaterinburgRussian Federation
  2. 2.Ural Federal University named after the First President of Russia B. N. EltsynEkaterinburgRussian Federation
  3. 3.Ural State Medical AcademyMinistry of Health Protection and Social DevelopmentEkaterinburgRussian Federation
  4. 4.Institute of ElectrophysicsUral Branch of the Russian Academy of SciencesEkaterinburgRussian Federation

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