Synthesis of mannose-containing neoglycolipids as a component of targeted delivery system for transfer of nucleic acids into antigen-presenting cells
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Two approaches to the preparation of mannose-containing neoglycolipid, designed for development of nonviral targeted delivery system for transfer of nucleic acids into antigen-presenting cells, were described. They differed from each other in the binding of the targeting ligand and the lipid anchor, which was effected either through the formation of an amide bond or via the chemoselective binding agent 3,4-diethoxycyclobut-3-ene-1,2-dione.
Key wordsneoglycolipid mannose targeting ligand 3,4-diethoxycyclobut-3-ene-1,2-dione antigen-presenting cell
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