Russian Chemical Bulletin

, Volume 61, Issue 7, pp 1497–1501 | Cite as

Synthesis of mannose-containing neoglycolipids as a component of targeted delivery system for transfer of nucleic acids into antigen-presenting cells

  • E. V. Shmendel’
  • A. A. Timakova
  • M. A. Maslov
  • N. G. Morozova
  • V. V. Chupin
Brief Communications


Two approaches to the preparation of mannose-containing neoglycolipid, designed for development of nonviral targeted delivery system for transfer of nucleic acids into antigen-presenting cells, were described. They differed from each other in the binding of the targeting ligand and the lipid anchor, which was effected either through the formation of an amide bond or via the chemoselective binding agent 3,4-diethoxycyclobut-3-ene-1,2-dione.

Key words

neoglycolipid mannose targeting ligand 3,4-diethoxycyclobut-3-ene-1,2-dione antigen-presenting cell 


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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • E. V. Shmendel’
    • 1
  • A. A. Timakova
    • 1
  • M. A. Maslov
    • 1
  • N. G. Morozova
    • 1
  • V. V. Chupin
    • 1
  1. 1.M. V. Lomonosov Moscow State University of Fine Chemical TechnologyMoscowRussian Federation

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