Abstract
Two approaches to the preparation of mannose-containing neoglycolipid, designed for development of nonviral targeted delivery system for transfer of nucleic acids into antigen-presenting cells, were described. They differed from each other in the binding of the targeting ligand and the lipid anchor, which was effected either through the formation of an amide bond or via the chemoselective binding agent 3,4-diethoxycyclobut-3-ene-1,2-dione.
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Based on the Materials of the XIX Mendeleev Congress on General and Applied Chemistry (September 25–30, 2011, Volgograd, Russia).
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1481–1484, July, 2012.
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Shmendel’, E.V., Timakova, A.A., Maslov, M.A. et al. Synthesis of mannose-containing neoglycolipids as a component of targeted delivery system for transfer of nucleic acids into antigen-presenting cells. Russ Chem Bull 61, 1497–1501 (2012). https://doi.org/10.1007/s11172-012-0194-3
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DOI: https://doi.org/10.1007/s11172-012-0194-3