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New tricyclic compounds with pyrimido[4,5-d]pyrimidine fragment, the 7,8-dihydro-1H-pyrimido[4,5,6-de]quinazoline derivatives

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Abstract

A reaction of 2-diaminomethylidenedimedone with aryl isocyanates leads to the formation of the corresponding ureas, which upon the action of sodium methoxide cyclize to 4-amino-7,8-dihydroquinazoline-2,5(1H,6H)-dione derivatives. The latter react with aryl isocyanates following the similar scheme to furnish 1,6-diaryl-8,8-dimethyl-7,8-dihydro-1H-pyrimido-[4,5,6-de]quinazoline-2,5(3H,6H)-diones, new tricyclic compounds containing pyrimidopyrimidine fragment.

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References

  1. Eur. Pat. Appl., EP 351058; Chem. Abstrs, 1990, 113, 40711r.

  2. J. Cieplic, J. Pluta, O. Gubrynowicz, Acta Pol. Pharm., 2003, 60, 487.

    Google Scholar 

  3. R. Gupta, A. Jain, R. Joshi, M. Jain, Bull. Korean Chem. Soc., 2011, 32, 899.

    Article  CAS  Google Scholar 

  4. Eur. Pat. Appl., EP 163599; Chem. Abstrs, 1986, 104, 186439u.

  5. Ger. Offen., DE 3601731; Chem. Abstrs, 1988, 109, 54786y.

  6. J. E. Gready, C. Mc Kinlay, M. G. Gebauer, Eur. J. Med. Chem., 2003, 38, 719.

    Article  Google Scholar 

  7. V. A. Dorokhov, M. F. Gordeev, A. V. Komkov, V. S. Bogdanov, Izv. Akad. Nauk SSSR, Ser. Khim., 1991, 159 [Bull. Acad. Sci. USSR, Div. Chem. Sci. (Engl. Transl.), 1991, 40, 142].

    Google Scholar 

  8. V. A. Dorokhov, M. F. Gordeev, A. V. Komkov, V. S. Bogdanov, Izv. Akad. Nauk SSSR, Ser. Khim., 1991, 2593 [Bull. Acad. Sci. USSR, Div. Chem. Sci. (Engl. Transl.), 1991, 40, 2267].

    Google Scholar 

  9. A. V. Komkov, A. M. Sakharov, V. S. Bogdanov, V. A. Dorokhov, Izv. Akad. Nauk, Ser. Khim., 1995, 1324 [Russ. Chem. Bull. (Engl. Transl.), 1995, 44, 1278].

    Google Scholar 

  10. V. Dorokhov, A. Komkov, S. Baranin, ARKIVOC, 2003, 14, 178, www.arkat-usa.org, volume 2003, 14.

    Google Scholar 

  11. V. A. Voronkova, A. V. Komkov, V. A. Dorokhov, Izv. Akad. Nauk, Ser. Khim., 2009, 347 [Russ. Chem. Bull., Int. Ed., 2009, 58, 351].

    Google Scholar 

  12. V. A. Dorokhov, V. A. Voronkova, A. V. Komkov, S. V. Baranin, L. S. Vasil’ev, Izv. Akad. Nauk, Ser. Khim., 2010, 1012 [Russ. Chem. Bull., Int. Ed., 2010, 59, 1035].

    Google Scholar 

  13. H. Wamhoff, W. Lamers, Synthesis, 1993, 111.

  14. V. A. Voronkova, A. V. Komkov, A. S. Shashkov, V. A. Dorokhov, Izv. Akad. Nauk, Ser. Khim., 2011, 141 [Russ. Chem. Bull., Int. Ed., 2011, 60, 148].

    Google Scholar 

  15. I. Trummer, E. Ziegler, O. S. Wolfbeis, Synthesis, 1981, 225.

  16. V. A. Mironov, A. D. Fedorovich, A. A. Akhrem, Usp. Khim., 1981, 50, 1272 [Russ. Chem. Rev. (Engl. Transl.), 1981, 50, 666].

    CAS  Google Scholar 

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Authors and Affiliations

  1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation

    V. A. Dorokhov, V. A. Voronkova, A. V. Komkov & A. S. Shashkov

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  1. V. A. Dorokhov
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  2. V. A. Voronkova
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  3. A. V. Komkov
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  4. A. S. Shashkov
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Correspondence to V. A. Dorokhov.

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Dedicated to Academician of the Russian Academy of Sciences O. M. Nefedov on the occasion of his 80th birthday.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 2275–2279, November, 2011.

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Dorokhov, V.A., Voronkova, V.A., Komkov, A.V. et al. New tricyclic compounds with pyrimido[4,5-d]pyrimidine fragment, the 7,8-dihydro-1H-pyrimido[4,5,6-de]quinazoline derivatives. Russ Chem Bull 60, 2320–2324 (2011). https://doi.org/10.1007/s11172-011-0355-9

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  • DOI: https://doi.org/10.1007/s11172-011-0355-9

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