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Russian Chemical Bulletin

, Volume 60, Issue 11, pp 2320–2324 | Cite as

New tricyclic compounds with pyrimido[4,5-d]pyrimidine fragment, the 7,8-dihydro-1H-pyrimido[4,5,6-de]quinazoline derivatives

  • V. A. Dorokhov
  • V. A. Voronkova
  • A. V. Komkov
  • A. S. Shashkov
Full Articles

Abstract

A reaction of 2-diaminomethylidenedimedone with aryl isocyanates leads to the formation of the corresponding ureas, which upon the action of sodium methoxide cyclize to 4-amino-7,8-dihydroquinazoline-2,5(1H,6H)-dione derivatives. The latter react with aryl isocyanates following the similar scheme to furnish 1,6-diaryl-8,8-dimethyl-7,8-dihydro-1H-pyrimido-[4,5,6-de]quinazoline-2,5(3H,6H)-diones, new tricyclic compounds containing pyrimidopyrimidine fragment.

Key words

2-diaminomethylidene-5,5-dimethylcyclohexane-1,3-dione aryl isocyanates 4-amino-7,8-dihydroquinazoline-2,5(1H,6H)-diones cyclization 7,8-dihydro-1H-pyrimido-[4,5,6-de]quinazoline-2,5(3H,6H)-dione derivatives [1,5]-hydride shift 

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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • V. A. Dorokhov
    • 1
  • V. A. Voronkova
    • 1
  • A. V. Komkov
    • 1
  • A. S. Shashkov
    • 1
  1. 1.N. D. Zelinsky Institute of Organic ChemistryRussian Academy of SciencesMoscowRussian Federation

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