Antiarrhythmic agents based on diterpenoid alkaloids

  • M. S. Yunusov


Diterpenoid alkaloids comprise a large group of natural compounds produced by the plants of the genera Aconitum and Delphinium. Some of these compounds were found to manifest valuable pharmacological properties, including the unique antiarrhythmic activity. Allapinine (derived from the alkaloid lappaconitine) was approved as a drug. The investigation of the structure—activity relationship revealed structural elements responsible for the arrhythmogenic and antiarrhythmic properties.

Key words

diterpenoid alkaloids antiarrhythmic agents arrhythmogenic agents structure—activity relationships 


  1. 1.
    M. H. Benn, J. M. Jacyno, The Toxicology and Pharmacology of Diterpenoid Alkaloids. Alkaloids. Chemical and Biological Perspectives, Ed. S. W. Pelletier, New York, 1983, p. 153.Google Scholar
  2. 2.
    A. N. Nevskii, Rod Delphinium L., Flora SSSR [Genus Delphinium L., Flora of the USSR], Izd-vo AN SSSR, Moscow, 1937, 7, 99 (in Russian); E. I. Shteinberg, Rod Aconitum, Flora SSSR [Genus Aconitum, Flora of the USSR], Izd-vo AN SSSR, Moscow, 1937, 7, 183 (in Russian); N. N. Fedorov, Rod Delphinium L. na yuzhnom Urale [Genus Delphinium L. at the Southern Urals], Gilem, Ufa, pp. 2003 (in Russian); M. S. Yunusov, Khim. Interes. Ustoichivogo Razvitiya 1997, 41 [Chemistry for Sustainable Development (Engl. Transl.), 1997].Google Scholar
  3. 3.
    F. N. Dzhakhangirov, M. N. Sultankhodzhaev, B. Tashkhodzhaev, B. T. Salimov, Khim. Prirod. Soedin., 1997, 254 [Chem. Natural Comp. (Engl. Transl.) 1997, 33, 190].Google Scholar
  4. 4.
    Yu. N. Zamataev, Yu. A. Kremnev, N. A. Grinenko, S. E. Podshibyakin, Russ. Med. Zh. [Russ. Med. J.], 2003, 9 (in Russian).Google Scholar
  5. 5.
    L. G. Nabelyanskaya, Farmakol. Toksikol. [Pharmac. Toxicol.], 1959, 38 (in Russian).Google Scholar
  6. 6.
    USSR Inventor’s Certificate No. 1335293, Byul. Izobr. [Inventor Bull.], 1987, 33 (in Russian).Google Scholar
  7. 7.
    S. F. Sokolov, F. N. Dzhakhangirov, Kardiologiya [Cardiology], 2002, 96 (in Russian).Google Scholar
  8. 8.
    V. S. Gasilin, E. V. Dorofeev, N. K. Rozova, Kardiologiya [Cardiology], 1990, 30 (in Russian).Google Scholar
  9. 9.
    F. N. Dzhakhangirov, E. G. Sirotenko, Ya. V. Rashkes, DTAN Uzb. SSR [Dokl. Acad. Sci. Uzb. SSR], 1990, 44 (in Russian).Google Scholar
  10. 10.
    V. A. Rulin, N. A. Mazur, G. M. Zaitseva, Khim.-farm. Zh., 1988, 399 [Pharm. Chem. J. (Engl. Transl.), 1988].Google Scholar
  11. 11.
    RF Pat. 2180583, Byul. Izobr. [Inventor Bull.], 2002, 8 (in Russian).Google Scholar
  12. 12.
    RF Pat. 2228334, Byul. Izobr. [Inventor Bull.], 2004, 13 (in Russian).Google Scholar
  13. 13.
    USSR Inventor’s Certificate No. 1577293, Byul. Izobr. [Inventor Bull.], 1990, 25 (in Russian).Google Scholar
  14. 14.
    V. E. Nezhevenko, M. S. Yunusov, S. Yu. Yunusov, Khim. Prirod. Soedin., 1975, 389 [Chem. Natural Comp. (Engl. Transl.), 1975, 11, 400].Google Scholar
  15. 15.
    M. N. Sultankhodzhaev, M. S. Yunusov, S. Yu. Yunusov, Khim. Prirod. Soedin., 1975, 381 [Chem. Natural Comp. (Engl. Transl.), 1975, 11, 392].Google Scholar
  16. 16.
    N. Kh. Shakhidoyatova, F. N. Dzhakhangirov, M. N. Sultankhodzhaev, Pharmac. Chem. J., 2001, 35, 266.CrossRefGoogle Scholar
  17. 17.
    Z. M. Vaisov, B. T. Salimov, B. Tashkhodzhaev, M. S. Yunusov, Khim. Prirod. Soedin., 1986, 658 [Chem. Natural Comp. (Engl. Transl.), 1986, 22, 623].Google Scholar
  18. 18.
    B. T. Salimov, Zh. Kh. Kuzibaeva, F. N. Dzhakhangirov, Khim. Prirod. Soedin., 1996, 384 [Chem. Natural Comp. (Engl. Transl.), 199, 32, 366].Google Scholar
  19. 19.
    USSR Pat. 963242; Byul. Izobr. [Inventor Bull.], 1982, 36.Google Scholar
  20. 20.
    B. T. Sagdullaev, F. Yu. Abramov, A. I. Gagel’gans, F. N. Dzhakhangirov, P. B. Usmanov, Khim. Prirod. Soedin., 1998, 523 [Chem. Natural Comp. (Engl. Transl.), 1998, 34, 480].Google Scholar
  21. 21.
    USSR Inventor’s Certificate No. 1356405, Byul. Izobr. [Inventor Bull.], 1987, 44 (in Russian).Google Scholar
  22. 22.
    USSR Inventor’s Certificate No. 1394669, Byul. Izobr. [Inventor Bull.], 1988, 17 (in Russian).Google Scholar
  23. 23.
    USSR Inventor’s Certificate No. 1365667, Byul. Izobr. [Inventor Bull.], 1988, 1 (in Russian).Google Scholar

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  1. 1.Institute of Organic ChemistryUfa Scientific Center of the Russian Academy of SciencesUfaRussian Federation

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