Antiarrhythmic agents based on diterpenoid alkaloids



Diterpenoid alkaloids comprise a large group of natural compounds produced by the plants of the genera Aconitum and Delphinium. Some of these compounds were found to manifest valuable pharmacological properties, including the unique antiarrhythmic activity. Allapinine (derived from the alkaloid lappaconitine) was approved as a drug. The investigation of the structure—activity relationship revealed structural elements responsible for the arrhythmogenic and antiarrhythmic properties.

Key words

diterpenoid alkaloids antiarrhythmic agents arrhythmogenic agents structure—activity relationships 


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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  1. 1.Institute of Organic ChemistryUfa Scientific Center of the Russian Academy of SciencesUfaRussian Federation

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