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Russian Chemical Bulletin

, Volume 59, Issue 3, pp 632–636 | Cite as

Base-catalyzed intramolecular heterocyclization of o-alkynylbenzhydrazides

  • T. F. Mikhailovskaya
  • S. F. Vasilevsky
Article

Abstract

The reaction of methyl o-(2-R-ethynyl)benzoates with hydrazine affords either fused 4-R-methylphthalazin-1-ones or 2-amino-3-R-methylideneisoindolin-1-ones. The latter are on treatment with KOH undergo recyclization into the corresponding 4-R-methylphthalazin-1-ones.

Key words o-alkynylbenzhydrazides cross-coupling heterocyclization recyclization isoin-dolinones phthalazinones 

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Copyright information

© Springer Science+Business Media, Inc.  2010

Authors and Affiliations

  1. 1.Institute of Chemical Kinetics and CombustionSiberian Branch of the Russian Academy of ScienceNovosibirskRussian Federation

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