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Russian Chemical Bulletin

, Volume 58, Issue 7, pp 1504–1508 | Cite as

Three-component condensation of 5-aminopyrazole derivatives with isatins and Meldrum’s acid. Synthesis of 1,7-dihydrospiro[pyrazolo[3,4-b]-pyridine-4,3′-indole]-2′,6(1′H,5H)-diones

  • B. V. Lichitsky
  • A. N. Komogortsev
  • A. A. Dudinov
  • M. M. Krayushkin
Full Articles

Abstract

A new method for the synthesis of hitherto unknown substituted 1,7-dihydrospiro-[pyrazolo[3,4-b]pyridine-4,3′-indole]-2′,6(1′H,5H)-diones based on three-component condensation of 5-aminopyrazoles with Meldrum’s acid and isatins is developed.

Key words

isatins three-component condensation Meldrum’s acid 5-aminopyrazoles decarboxylation 1,7-dihydrospiro[pyrazole[3,4-b]pyridine-4,3′-indole]-2′,6(1′H,5H)-diones 

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Copyright information

© Springer Science+Business Media, Inc.  2009

Authors and Affiliations

  • B. V. Lichitsky
    • 1
  • A. N. Komogortsev
    • 1
  • A. A. Dudinov
    • 1
  • M. M. Krayushkin
    • 1
  1. 1.N. D. Zelinsky Institute of Organic ChemistryRussian Academy of SciencesMoscowRussian Federation

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