Russian Chemical Bulletin

, Volume 58, Issue 4, pp 844–850 | Cite as

4-Alkoxycarbonyl-2-(2-pyridyl)thiazoles and their complexes with CuII and CoII. Molecular and crystal structure of copper 4-ethoxycarbonyl-2-(2-pyridyl)thiazole dichloride

  • A. G. Majouga
  • E. K. Beloglazkina
  • V. V. Frolov
  • A. A. Moiseeva
  • N. V. Zyk
Full Articles


The first synthesis of ethyl 2-(2-pyridyl)thiazole4-carboxylate ( 2) and bis[2-(2-pyridylthiazol-4-ylcarbonyloxy)ethyl] disulfide ( 4) is described. The complexation of compounds 2 and 4 with CuII, CoII, and NiII chlorides and perchlorates has been studied. Electrochemical behavior of the ligands and complexes obtained has been investigated by cyclic voltammetry and using rotating disk electrode, which allowed us to confirm the possibility for the ligand 4 and its complexes to be adsorbed on the surface of a gold electrode.

copper(II) cobalt(II) nickel(II) transition metal complexes thiazoles ligands electrochemistry 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    D.-F. Shi, T. D. Bratshaw, S. Wrigley, C. J. McCall, P. Lelieveld, I. Fichtner, M. F. G. Stevens, J. Med. Chem., 1996, 39, 3375.CrossRefGoogle Scholar
  2. 2.
    T. D. Bratshaw, S. Wrigley, D.-F. Shi, R. J. Schultz, K. D. Paull, M. F. G. Stevens, Br. J. Cancer, 1998, 77, 745.Google Scholar
  3. 3.
    M. Lezkano, W. Al-Soufi, M. Novo, E. Rodriguez-Nunez, J. V. Tato, J. Agric. Food Chem., 2002, 50, 108.CrossRefGoogle Scholar
  4. 4.
    Z.-P. Zuang, M.-P. Kung, A. Wilson, C.-W. Lee, K. Plossl, C. Hou, D. M. Holtzmann, H. F. Kung, J. Med. Chem., 2003, 46, 237.CrossRefGoogle Scholar
  5. 5.
    G. Wells, J. M. Berry, T. D. Bratshaw, A. M. Burger, A. Seaton, B. Wang, A. D. Westwell, M. F. G. Stevens, J. Med. Chem., 2003, 46, 532.CrossRefGoogle Scholar
  6. 6.
    D. J. Skalitzki, J. T. Marakovits, K. A. Maegley, A. Ekker, X.-H. Yu, Z. Hostomsky, S. E. Webber, B. W. Eastman, R. Almassy, J. Li, N. J. Curtin, D. R. Newell, A. H. Calvert, R. J. Griffin, B. T. Golding, J. Med. Chem., 2003, 46, 210.CrossRefGoogle Scholar
  7. 7.
    J. A. Grim, H. G. Petring, Cancer Res., 1967, 27, 1278.Google Scholar
  8. 8.
    B. Xie, L. J. Wilson, D. M. Stanbury, Inorg. Chem., 2001, 40, 3606.CrossRefGoogle Scholar
  9. 9.
    E. K. Beloglazkina, I. V. Yudin, A. G. Majouga, A. A. Moiseeva, A. I. Tursina, N. V. Zyk, Izv. Akad. Nauk, Ser. Khim., 2006, 1738 [Russ. Chem. Bull., Int. Ed., 2006, 55, 1803].Google Scholar
  10. 10.
    B. Baker, G. Lourens, J. Med. Chem., 1969, 12, 95.CrossRefGoogle Scholar
  11. 11.
    V.-M. Mukkala, P. Liitti, I. Hemmilä, H. Takalo, C. Matachescu, J. Kankare, Helv. Chim. Acta, 1996, 79, 295.CrossRefGoogle Scholar
  12. 12.
    J. J. P. Stewart, J. Comput. Chem., 1989, 10, 209.CrossRefGoogle Scholar
  13. 13.
    B. S. Paranjon-Kosta, E. J. Baran, O. E. Piro, Polyhedron, 1997, 16, 3379.CrossRefGoogle Scholar
  14. 14.
    H. Hagenstrom, M. A. Schneeweiss, D. M. Kolb, Langmuir, 1999, 15, 2435.CrossRefGoogle Scholar
  15. 15.
    J. Zhang, Q. Chi, J. U. Nielsen, E. P. Friis, J. E. T. Andersen, J. Ulstrup, Langmuir, 2000, 16, 7229.CrossRefGoogle Scholar
  16. 16.
    F. Loglio, M. Schweizer, D. M. Kolb, Langmuir, 2003, 19, 830.CrossRefGoogle Scholar
  17. 17.
    M. Sheldrick, Acta Crystallogr., Sect. A, 1990, 46, 467.CrossRefGoogle Scholar
  18. 18.
    G. M. Sheldrick, SHELXL-97. Program for the Refinement of Crystal Structures, University of Göttingen, Göttingen, Germany, 1997.Google Scholar
  19. 19.
    L. Cassar, S. Panossian, C. Giordano, Synthesis, 1978, 917.Google Scholar
  20. 20.
    T. S. Gardner, E. Wenis, J. W. Lee, J. Org. Chem., 1954, 19, 753.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, Inc.  2009

Authors and Affiliations

  • A. G. Majouga
    • 1
  • E. K. Beloglazkina
    • 1
  • V. V. Frolov
    • 1
  • A. A. Moiseeva
    • 1
  • N. V. Zyk
    • 1
  1. 1.Department of ChemistryM. V. Lomonosov Moscow State UniversityMoscowRussian Federation

Personalised recommendations