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Russian Chemical Bulletin

, Volume 58, Issue 3, pp 499–501 | Cite as

Study on effects of modification conditions of powdered nickel-cobalt catalysts on enantioselectivity of hydrogenation of ethyl acetoacetate

  • N. D. Zubareva
  • G. V. Dorokhin
  • E. I. Klabunovskii
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  • 40 Downloads

Abstract

An effect of modification conditions of powdered nickel-cobalt catalysts on enantioselectivity of hydrogenation of ethyl acetoacetate has been studied. Addition of NaBr to the modifying solution of RR-(+)-tartaric acid does not improve enantioselectivity of the catalyst. When the Ni-Co catalysts are modified with amino acids, the best results are obtained with L-β-phenylalanine (17% ee).

Key words

enantioselective catalytic hydrogenation bimetallic Ni-Co catalysts ethyl acetoacetate modification optically active ethyl hydroxybutyrate 

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Copyright information

© Springer Science+Business Media, Inc.  2009

Authors and Affiliations

  • N. D. Zubareva
    • 1
  • G. V. Dorokhin
    • 1
  • E. I. Klabunovskii
    • 1
  1. 1.N. D. Zelinsky Institute of Organic ChemistryRussian Academy of SciencesMoscowRussian Federation

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