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Russian Chemical Bulletin

, 57:2353 | Cite as

Reactions of ethyl 4-amino-6-(ethoxycarbonylmethyl)-2-phenylpyrimidine-5-carboxylate with hydrazines

  • A. V. Komkov
  • A. S. Shashkov
  • V. A. Dorokhov
Full Articles

Abstract

New substituted 4,6-diamino-7-hydroxypyrido[4,3-d]pyrimidin-5(6H)-ones were synthe-sized by treatment of ethyl 4-amino-6-(ethoxycarbonylmethyl)-2-phenylpyrimidine-5-car-boxylic acid with hydrazine hydrate and phenylhydrazine. In the case of methylhydrazine, the reaction proceeded in an unusual way and afforded a product identified, relying on NMR data, as functionally substituted 8-(5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-7-ylidene)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine comprising two amineimide fragments. A diacetyl derivative of this compound was obtained.

Key words

ethyl 4-amino-6-(ethoxycarbonylmethyl)-2-phenylpyrimidine-5-carboxylate hydrazines substituted pyrido[4,3-d]pyrimidines heterocyclization 

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Copyright information

© Springer Science+Business Media, Inc.  2008

Authors and Affiliations

  • A. V. Komkov
    • 1
  • A. S. Shashkov
    • 1
  • V. A. Dorokhov
    • 1
  1. 1.N. D. Zelinsky Institute of Organic ChemistryMoscowRussian Federation

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