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Russian Chemical Bulletin

, Volume 57, Issue 7, pp 1534–1538 | Cite as

Synthesis and transformations of 3-acetylpyridine-2(1H)-thiones

  • V. K. Zav’yalova
  • A. A. Zubarev
  • V. P. Litvinov
Full Articles

Abstract

Reactions of substituted 3-cyanopyridine-2(1H)-thiones with methyllithium gave 3-acetylpyridine-2(1H)-thiones. The best results were achieved by adding a solid-state thione to a solution of methyllithium in ether (thione: MeLi = 1: 3). The compounds obtained and their 3-pentanoyl analogs were used to synthesize a number of fused heterocyclic systems.

Key words

3-cyanopyridine-2(1H)-thiones 3-acetylpyridine-2(1H)-thiones 3-pentanoylpyridine-2(1H)-thiones methyllithium thieno[2,3-b]pyridines 3-cyanopyrido[2,3-b]thiopyrans 4,8-dialkyl-2-cyanomethylidenepyrido[2,3-b][1,3]thiazines 

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Copyright information

© Springer Science+Business Media, Inc.  2008

Authors and Affiliations

  • V. K. Zav’yalova
    • 1
  • A. A. Zubarev
    • 1
  • V. P. Litvinov
    • 1
  1. 1.N. D. Zelinsky Institute of Organic ChemistryRussian Academy of SciencesMoscowRussian Federation

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