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Russian Chemical Bulletin

, Volume 57, Issue 6, pp 1257–1263 | Cite as

Three-component condensation of diethyl isophthaloyldiacetate, aromatic aldehyde, and urea as a new method for the synthesis of 1,3-bis(2-oxo-1,2,3,4-tetrahydropyrimidin-6-yl)benzenes

  • V. A. Mamedov
  • S. V. Vdovina
  • E. I. Vorkunova
  • L. V. Mustakimova
  • A. F. Saifina
  • A. T. Gubaidullin
  • I. Kh. Rizvanov
  • Ya. A. Levin
  • I. A. Litvinov
Article

Abstract

Condensation of diethyl isophthaloyldiacetate, aromatic aldehyde, and urea in the presence of Me3SiCl proceeds efficiently and faster than in the absence of the latter to form 1,3-bis(2-oxo-1,2,3,4-tetrahydropyrimidin-6-yl)benzene derivatives capable to give inclusion complexes with DMF.

Key words

diethyl isophthaloyldiacetate the Biginelli reaction 2-oxo-1,2,3,4-tetrahydropyrimidines trimethylsilyl chloride NMR spectra X-ray analysis 

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Copyright information

© Springer Science+Business Media, Inc.  2008

Authors and Affiliations

  • V. A. Mamedov
    • 1
  • S. V. Vdovina
    • 1
  • E. I. Vorkunova
    • 1
  • L. V. Mustakimova
    • 1
  • A. F. Saifina
    • 1
  • A. T. Gubaidullin
    • 1
  • I. Kh. Rizvanov
    • 1
  • Ya. A. Levin
    • 1
  • I. A. Litvinov
    • 1
  1. 1.A. E. Arbuzov Institute of Organic and Physical ChemistryKazan Scientific Center of the Russian Academy of SciencesKazanRussian Federation

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