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Russian Chemical Bulletin

, Volume 56, Issue 12, pp 2471–2478 | Cite as

Polyfused nitrogen-containing heterocycles 18. 2′-Amino-5-methyl-1,2,3,4,4′,5′-hexahydrospiro[quinoxaline-2,4′-thiazol]-3-ones. Synthesis, structure, and recyclization

  • V. A. Mamedov
  • A. A. Kalinin
  • A. T. Gubaidullin
  • I. A. Litvinov
Article

Abstract

Bis-3-(α-bromoethyl)quinoxalin-2-ones with 3-oxapentane or 3,6-dioxaoctane spacer binding two heterocyclic fragments react with thiourea to give the corresponding bis-spirothiazoloquinoxalines, which upon treatment with acetic anhydride can be converted to podands with terminal thiazoloannulated quinoxaline fragments. X-Ray data for 2′-amino-4-ethyl-5-methyl-1,2,3,4,4′,5′-hexahydrospiro[quinoxaline-2,4′-thiazol]-3-one indicate for this compound a potentiality to form clathrate structures with various solvate molecules.

Key words

3-(α-bromoethyl)quinoxalin-2-ones spirothiazoloquinoxalines thiazolo[3,4-a]quinoxalines recyclization podands IR spectroscopy NMR spectroscopy X-ray analysis 

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Copyright information

© Springer Science+Business Media, Inc.  2007

Authors and Affiliations

  • V. A. Mamedov
    • 1
  • A. A. Kalinin
    • 1
  • A. T. Gubaidullin
    • 1
  • I. A. Litvinov
    • 1
  1. 1.A. E. Arbuzov Institute of Organic and Physical ChemistryKazan Research Center of the Russian Academy of SciencesKazanRussian Federation

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