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Russian Chemical Bulletin

, Volume 56, Issue 7, pp 1474–1476 | Cite as

The Mannich reaction in the synthesis of N,S-containing heterocycles 6. New approaches to the synthesis of pyrimido[4,3-b][1,3,5]thiadiazine derivatives

  • V. V. Dotsenko
  • S. G. Krivokolysko
  • V. P. Litvinov
Article

Abstract

Aminomethylation of 2,6-diamino-4-aryl-4H-thiopyran-3,5-dicarbonitriles in the Mannich reaction with p-toluidine and formaldehyde unexpectedly gave pyrimido[4,3-b][1,3,5]thiadiazine derivatives. The same compounds were obtained in an independent way involving a multicomponent cascade condensation of aromatic aldehydes, cyanothioacetamide, p-toluidine, and formaldehyde.

Key words

pyrimido[4,3-b][1,3,5]thiadiazines aminomethylation the Mannich reaction multicomponent cascade synthesis 2,6-diamino-4-aryl-4H-thiopyran-3,5-dicarbonitriles 

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Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  • V. V. Dotsenko
    • 1
  • S. G. Krivokolysko
    • 1
  • V. P. Litvinov
    • 2
  1. 1.ChemEx LaboratoryV. Dal’ East-Ukrainian National UniversityLuganskthe Ukraine
  2. 2.N. D. Zelinsky Institute of Organic ChemistryRussian Academy of SciencesMoscowRussian Federation

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