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New carborane-containing amino acids and their derivatives. Crystal structures of n-protected carboranylalaninates

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Russian Chemical Bulletin Aims and scope

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Abstract

New alanine derivatives containing both the carboranyl and trifluoromethyl groups were synthesized by the reaction of organometallic derivatives of o-carborane with methyl trifluoropyruvate imines. When using the 1R-(−)-menthoxycarbonyl protecting group at the nitrogen atom, one of diastereomers was isolated and characterized. Trifluoromethyl-carboranylalanine methyl esters containing different protecting groups at the nitrogen atom were studied by X-ray diffraction. Both complete and partial deprotection of the amino and carboxy groups was performed.

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Authors and Affiliations

  1. A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 ul. Vavilova, 119991, Moscow, Russian Federation

    S. V. Timofeev, V. I. Bregadze, S. N. Osipov, P. V. Petrovskii, Z. A. Starikova & I. V. Glukhov

  2. Department of Chemistry, M. V. Lomonosov Moscow State University, 1 Leninskie Gory, 119992, Moscow, Russian Federation

    I. D. Titanyuk & I. P. Beletskaya

Authors
  1. S. V. Timofeev
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  2. V. I. Bregadze
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  3. S. N. Osipov
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  4. I. D. Titanyuk
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  5. P. V. Petrovskii
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  6. Z. A. Starikova
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  7. I. V. Glukhov
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  8. I. P. Beletskaya
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Corresponding author

Correspondence to V. I. Bregadze.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 4, pp. 761–767, April, 2007.

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Timofeev, S.V., Bregadze, V.I., Osipov, S.N. et al. New carborane-containing amino acids and their derivatives. Crystal structures of n-protected carboranylalaninates. Russ Chem Bull 56, 791–797 (2007). https://doi.org/10.1007/s11172-007-0118-9

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  • DOI: https://doi.org/10.1007/s11172-007-0118-9

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