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Russian Chemical Bulletin

, Volume 56, Issue 4, pp 791–797 | Cite as

New carborane-containing amino acids and their derivatives. Crystal structures of n-protected carboranylalaninates

  • S. V. Timofeev
  • V. I. Bregadze
  • S. N. Osipov
  • I. D. Titanyuk
  • P. V. Petrovskii
  • Z. A. Starikova
  • I. V. Glukhov
  • I. P. Beletskaya
Article

Abstract

New alanine derivatives containing both the carboranyl and trifluoromethyl groups were synthesized by the reaction of organometallic derivatives of o-carborane with methyl trifluoropyruvate imines. When using the 1R-(−)-menthoxycarbonyl protecting group at the nitrogen atom, one of diastereomers was isolated and characterized. Trifluoromethyl-carboranylalanine methyl esters containing different protecting groups at the nitrogen atom were studied by X-ray diffraction. Both complete and partial deprotection of the amino and carboxy groups was performed.

Key words

amino acids alanine organofluorine compounds imines carboranes X-ray diffraction study 

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Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  • S. V. Timofeev
    • 1
  • V. I. Bregadze
    • 1
  • S. N. Osipov
    • 1
  • I. D. Titanyuk
    • 2
  • P. V. Petrovskii
    • 1
  • Z. A. Starikova
    • 1
  • I. V. Glukhov
    • 1
  • I. P. Beletskaya
    • 2
  1. 1.A. N. Nesmeyanov Institute of Organoelement CompoundsRussian Academy of SciencesMoscowRussian Federation
  2. 2.Department of ChemistryM. V. Lomonosov Moscow State UniversityMoscowRussian Federation

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