Russian Chemical Bulletin

, Volume 55, Issue 1, pp 62–65 | Cite as

Synthesis and antitumor properties of new platinum(IV) complexes with aminonitroxyl radicals

  • V. D. Sen’
  • V. A. Golubev
  • N. Yu. Lugovskaya
  • T. E. Sashenkova
  • N. P. Konovalova


Acylation of cis,trans,cis-PtIV(RNH2)(NH3)(OH)2Cl2 with acetic anhydride afforded complexes cis,trans,cis-PtIV(RNH2)(NH3)(OAc)2Cl2, where R is 2,2,6,6-tetramethyl-1-oxylpiperidin-4-yl (1b) or 2,2,5,5-tetramethyl-1-oxylpyrrolidin-3-yl (2b). The complexes were characterized by elemental analysis, HPLC, and IR, UV, and ESR spectra. Complex 1b exhibits high antitumor activity comparable with that of Cisplatin against leukemia P388 used as the experimental tumor. Simultaneous administration of low doses of 1b and Cisplatin (1/20 of LD50 each) results in synergism of the antitumor activity and 100% cure of animals.

Key words

platinum(IV) complexes nitroxyl radicals antitumor activity Cisplatin synergism 


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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • V. D. Sen’
    • 1
  • V. A. Golubev
    • 1
  • N. Yu. Lugovskaya
    • 1
  • T. E. Sashenkova
    • 1
  • N. P. Konovalova
    • 1
  1. 1.Institute of Problems of Chemical PhysicsRussian Academy of SciencesChernogolovka, Moscow RegionRussian Federation

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