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Russian Chemical Bulletin

, Volume 55, Issue 1, pp 62–65 | Cite as

Synthesis and antitumor properties of new platinum(IV) complexes with aminonitroxyl radicals

  • V. D. Sen’
  • V. A. Golubev
  • N. Yu. Lugovskaya
  • T. E. Sashenkova
  • N. P. Konovalova
Article

Abstract

Acylation of cis,trans,cis-PtIV(RNH2)(NH3)(OH)2Cl2 with acetic anhydride afforded complexes cis,trans,cis-PtIV(RNH2)(NH3)(OAc)2Cl2, where R is 2,2,6,6-tetramethyl-1-oxylpiperidin-4-yl (1b) or 2,2,5,5-tetramethyl-1-oxylpyrrolidin-3-yl (2b). The complexes were characterized by elemental analysis, HPLC, and IR, UV, and ESR spectra. Complex 1b exhibits high antitumor activity comparable with that of Cisplatin against leukemia P388 used as the experimental tumor. Simultaneous administration of low doses of 1b and Cisplatin (1/20 of LD50 each) results in synergism of the antitumor activity and 100% cure of animals.

Key words

platinum(IV) complexes nitroxyl radicals antitumor activity Cisplatin synergism 

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References

  1. 1.
    L. R. Kelland, in Uses of Inorganic Chemistry in Medicine, Ed. N. P. Farrell, Springer, Berlin, 1999, 109.Google Scholar
  2. 2.
    V. D. Sen’, V. A. Golubev, L. M. Volkova, and N. P. Konovalova, J. Inorg. Biochem., 1996, 64, 69.CrossRefGoogle Scholar
  3. 3.
    V. D. Sen’, A. V. Kulikov, A. V. Shugalii, and N. P. Konovalova, Izv. Akad. Nauk, Ser. Khim., 1998, 1640 [Russ. Chem. Bull., 1998, 47, 1598 (Engl. Transl.)].Google Scholar
  4. 4.
    V. D. Sen’, N. A. Rukina, V. V. Tkachev, A. V. Pis’menskii, L. M. Volkova, S. A. Goncharova, T. A. Raevskaya, A. G. Tikhomirov, L. B. Gorbacheva, and N. P. Konovalova, Izv. Akad. Nauk, Ser. Khim., 2000, 1624 [Russ. Chem. Bull., Int. Ed., 2000, 49, 1613].Google Scholar
  5. 5.
    V. D. Sen’, V. V. Tkachev, L. M. Volkova, S. A. Goncharova, T. A. Raevskaya, and N. P. Konovalova, Izv. Akad. Nauk, Ser. Khim., 2003, 403 [Russ. Chem. Bull., Int. Ed., 2003, 52, 421].Google Scholar
  6. 6.
    N. P. Konovalova, G. N. Bogdanov, V. B. Miller, E. G. Rozantsev, M. B. Neiman, and N. M. Emanuel’, Dokl. Akad. Nauk SSSR, 1964, 157, 707 [Dokl. Akad. Nauk SSSR, 1964, 157 (Engl. Transl.)].Google Scholar
  7. 7.
    M. Klimek, Nature, 1966, 209, 1256.Google Scholar
  8. 8.
    M. B. Gariboldi, S. Lucchi, C. Caserini, R. Supino, C. Oliva, and E. Monti, Free Radic. Biol. Med., 1998, 24, 913.CrossRefGoogle Scholar
  9. 9.
    V. D. Sen’, V. A. Golubev, I. V. Kulyk, and E. G. Rozantsev, Izv. Akad. Nauk, Ser. Khim., 1976, 403 [Bull. Acad. Sci. USSR, Div. Chem. Sci., 1976, 25 (Engl. Transl.)].Google Scholar
  10. 10.
    S. Goldstein, G. Merenuj, A. Russo, and A. Samuni, J. Am. Chem. Soc., 2003, 125, 789.CrossRefGoogle Scholar
  11. 11.
    N. M. Emanuel and N. P. Konovalova, in Bioactive Spin Labels, Ed. R. I. Zhdanov, Springer, Berlin, 1992, 439.Google Scholar
  12. 12.
    V. D. Sen’, A. V. Shugalii, and A. V. Kulikov, Izv. Akad. Nauk, Ser. Khim., 2002, 972 [Russ. Chem. Bull., Int. Ed., 2002, 51, 1058].Google Scholar
  13. 13.
    Eksperimental’naya otsenka protivoopukholevykh preparatov v SSSR i SShA [Experimental Estimation of Antitumor Drugs in the USSR and USA], Eds Z. Sof’ina, A. Syrkin, A. Goldin, A. Klyain, Meditsina, Moscow, 1980, 296 pp. (in Russian).Google Scholar
  14. 14.
    S. Choi, C. Filotto, M. Bisanzo, S. Delaney, D. Legasse, J. L. Whitworth, A. Jasco, C. Le, N. A. Wood, J. Willngham, A. Schwenker, and K. Spaulding, Inorg. Chem., 1998, 37, 2500.CrossRefGoogle Scholar
  15. 15.
    V. A. Golubev, V. D. Sen’, I. V. Kulyk, and A. L. Aleksandrov, Izv. Akad. Nauk, Ser. Khim., 1975, 2235 [Bull. Acad. Sci. USSR, Div. Chem. Sci., 1975, 24, 2119 (Engl. Transl.)].Google Scholar
  16. 16.
    J. L. Carr, M. D. Tingle, and M. J. McKeage, Cancer Chemother. Pharmacol., 2002, 50, 9.CrossRefGoogle Scholar
  17. 17.
    G. Mathe, E. Chenu, and C. Borout, Invest. New Drugs, 1989, 7, 404.Google Scholar
  18. 18.
    O. Rixe, W. Ortuzar, M. Alvarez, R. Parker, E. Reed, K. Paull, and T. Fojo, Biochem. Pharmacol., 1996, 52, 1855.CrossRefGoogle Scholar
  19. 19.
    S. Adachi, T. Ogasawara, E. Wakimoto, Y. Tsuji, T. Takemura, K. Koyama, Y. Takayasu, J. Inoue, and N. Nakao, Cancer, 2001, 91, 74.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • V. D. Sen’
    • 1
  • V. A. Golubev
    • 1
  • N. Yu. Lugovskaya
    • 1
  • T. E. Sashenkova
    • 1
  • N. P. Konovalova
    • 1
  1. 1.Institute of Problems of Chemical PhysicsRussian Academy of SciencesChernogolovka, Moscow RegionRussian Federation

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