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L-Glutamic Acid Modulates the Cytotoxic Effect of Tumor Necrosis Factor on the HL-60 Cell Line

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Abstract

L-Glutamic acid was shown to increase the stability of cells of the HL-60 line of human promyelocyte leukemia to the cytotoxic action of tumor necrosis factor alpha (TNF-α) due to the inhibition of apoptotic and NF-κB-activating cascades induced by this cytokine. At the same time, L-glutamic acid increases the TNF-α-mediated differentiating signal and the accompanying enhancement of the phosphatidylinositol-specific phospholipase C activity. Therefore, it is a promising agent for the reduction of total toxicity and inflammatory processes during treatment with TNF-α.

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Abbreviations

FADD:

Fas-Associated Death Domain Protein

FITC:

fluorescein isothiocyanate

IP1–3 :

inositol mono-, di-, and triphosphates

PBS:

phosphate-buffered saline

PI-PLC:

phosphatidylinositol-specific phospholipase C

PIP2 :

phosphatidylinositol 4,5-bisphosphate

PIP5K:

4-phosphate-5-kinase

RIP:

TNF-α-Receptor Interacting Protein

TNF-α:

Tumor Necrosis Factor alpha

TNF-R*:

receptor of TNFα

TRADD:

TNF-R1-Associated Death Domain Protein

TRAF:

TNF-Receptor-Associated Factor

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Authors and Affiliations

  1. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia

    N. V. Gibanova, T. V. Rakitina, S. S. Zhokhov, V. M. Lipkin & I. A. Kostanyan

  2. Research and Technology Institute of Biologically Active Substances, Vector State Scientific Center for Virology and Biotechnology, a/ya 112, Berdsk, Novosibirsk oblast, 633190, Russia

    N. M. Pustoshilova

Authors
  1. N. V. Gibanova
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  2. T. V. Rakitina
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  3. S. S. Zhokhov
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  4. N. M. Pustoshilova
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  5. V. M. Lipkin
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  6. I. A. Kostanyan
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Correspondence to I. A. Kostanyan.

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__________

Translated from Bioorganicheskaya Khimiya, Vol. 31, No. 6, 2005, pp. 602–608.

Original Russian Text Copyright © 2005 by Gibanova, Rakitina, Zhokhov, Pustoshilova, Lipkin, Kostanyan.

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Gibanova, N.V., Rakitina, T.V., Zhokhov, S.S. et al. L-Glutamic Acid Modulates the Cytotoxic Effect of Tumor Necrosis Factor on the HL-60 Cell Line. Russ J Bioorg Chem 31, 543–548 (2005). https://doi.org/10.1007/s11171-005-0074-9

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  • DOI: https://doi.org/10.1007/s11171-005-0074-9

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