Russian Journal of Bioorganic Chemistry

, Volume 31, Issue 3, pp 216–220 | Cite as

Spatial Structure of BAM-12P Dodecapeptide and Its Analogues

  • N. A. Akhmedov
  • Z. H. Tagiev
  • E. M. Hasanov
  • T. A. Makhmudova


Theoretical conformational analysis was used to study the spatial structure and conformational properties of the bovine adrenal medulla dodecapeptide BAM-12P (Tyr1-Gly2-Gly3-Phe4-Met5-Arg6-Arg7-Val8-Gly9-Arg10-Pro11-Glu12). Twenty-three low-energy conformations of the BAM-12P backbone were shown to represent the spatial structure of the peptide. The inverse structural problem was solved, and synthetic analogues of BAM-12P were proposed, the spatial structures of which correspond to a set of low-energy potentially physiologically active conformations of the natural dodecapeptide.

Key words

BAM-12P structure and function theoretical conformational analysis 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Mizuno, K., Minamino, N., Kandawa, K., and Matsuo, H., Biochem. Biophys. Res. Commun., 1980, vol. 95, pp. 1482–1488.CrossRefPubMedGoogle Scholar
  2. 2.
    Kupruszewski, G., Wiss. Beitr. M.-Luther-Univ. Halle Wittenberg, 1988, no. 32, pp. 218–240.Google Scholar
  3. 3.
    Popov, E.M., Int. J. Quantum Chem., 1979, vol. 16, pp. 707–737.CrossRefGoogle Scholar
  4. 4.
    Popov, E.M., Mol. Biol. (Moscow), 1985, vol. 19, pp. 1107–1138.Google Scholar
  5. 5.
    Popov, E.M., Strukturnaya organizatsiya belkov (Structural Organization of Proteins), Moscow: Nauka, 1989.Google Scholar
  6. 6.
    Akhmedov, N.A., Akverdieva, G.A., Godjaev, N.M., and Popov, E.M., Int. J. Pept. Protein Res., 1986, vol. 27, pp. 95–111.PubMedGoogle Scholar
  7. 7.
    Godjayev, N.M., Akyuz, S., and Akverdieva, G.A., J. Mol. Struct., 1997, vol. 403, pp. 95–110.CrossRefGoogle Scholar
  8. 8.
    Momany, F.A., Carruthers, L.M., Mc Guire, R.F., and Scheraga, H.A., J. Phys. Chem., 1974, vol. 78, pp. 1595–1620.CrossRefGoogle Scholar
  9. 9.
    Momany, F.A., Mc Guire, R.F., Burgess, A.W., and Scheraga, H.A., J. Phys. Chem., 1975, vol. 79, pp. 2361–2381.CrossRefGoogle Scholar
  10. 10.
    Popov, E.M., Dashevskii, V.G., Lipkind, G.M., and Arkhipova, S.F., Mol. Biol. (Moscow), 1968, vol. 2, pp. 612–620.Google Scholar
  11. 11.
    IUPAC-IUB Comission on Biochemical Nomenclature, Biochem. Biophys. Acta, 1971, vol. 229, pp. 1–17.Google Scholar
  12. 12.
    Popov, E.M., Godjaev, N.M., Akhmedov, N.A., and Suleymanova, E.V., Bioorg. Khim., 1990, vol. 16, pp. 482–491.PubMedGoogle Scholar
  13. 13.
    Akhmedov, N.A., Makhmudova, T.A., and Popov, E.M., Bioorg. Khim., 1993, vol. 19, pp. 623–628.PubMedGoogle Scholar
  14. 14.
    Popov, E.M., Bioorg. Khim., 1992, vol. 18, pp. 1229–1243.PubMedGoogle Scholar

Copyright information

© MAIK “Nauka/Interperiodica” 2005

Authors and Affiliations

  • N. A. Akhmedov
    • 1
  • Z. H. Tagiev
    • 2
  • E. M. Hasanov
    • 2
  • T. A. Makhmudova
    • 1
  1. 1.Baku State UniversityBakuAzerbaijan
  2. 2.Azerbaijan Medical UniversityBakuAzerbaijan

Personalised recommendations