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Synthesis and biological activity of novel 1,3,4-oxadiazole derivatives containing a pyrazole moiety

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Abstract

Several new 1,3,4-oxadiazole derivatives containing a pyrazole ring were designed and synthesized from ethyl acetoacetate and triethyl orthoformate as starting materials via multi-step reactions. The compound structures were confirmed by melting point, 1H NMR and HRMS. They were evaluated for fungicidal and herbicidal activities. Four of the compounds exhibited moderate fungicidal activity against Colletotrichum species. Most of the compounds had moderate-to-good activity as a herbicide.

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Acknowledgements

This work was funded by Zhejiang Provincial Natural Science Foundation of China (No. LY19C140002), Research Fund of Department of Education of Zhejiang Province (Y201941832) and the Opening Foundation of the Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Grant No. 2018GDGP0104.

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Authors and Affiliations

  1. College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, 310014, Zhejiang, China

    Wei Yu, Zhi-Wen Zhai, Hong-Ke Wu, Jian-Quan Weng, Cheng-Xia Tan & Xing-Hai Liu

  2. USDA ARS, Natural Products Utilization Research Unit, University, MS, 38677, USA

    David E. Wedge & Stephen O. Duke

  3. Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, Shandong, China

    Yong-Gang Zhang

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  1. Wei Yu
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Yu, W., Zhai, ZW., Wedge, D.E. et al. Synthesis and biological activity of novel 1,3,4-oxadiazole derivatives containing a pyrazole moiety. Res Chem Intermed 45, 5989–6001 (2019). https://doi.org/10.1007/s11164-019-04015-8

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