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An efficient synthesis of biaryl diamides via Ullmann coupling reaction catalyzed by CuI in the presence of Cs2CO3 and TBAB

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Abstract

CuI accompanyied by Cs2CO3 and TBAB was confirmed to be an efficient catalyst combination to promote an Ullmann coupling reaction. It facilitated 2-bromobenzamides to undergo a coupling reaction for the synthesis of symmetrical biaryldiamides in moderate yields at 120 °C under Pd-free conditions.

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Acknowledgements

This work was financially supported by NSFC of China (No. 21702078), the NSF of Jiangsu Province (No. BK20170231), the Priority Academic Program Development of Jiangsu Higher education Institutions and TAPP.

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Authors and Affiliations

  1. School of Chemistry and Materials Science, Jiangsu Key Laboratory of Green Synthesis for Functional Materials, Jiangsu Normal University, Xuzhou, Jiangsu, 221116, People’s Republic of China

    Fang Dong, Jian-Quan Liu & Xiang-Shan Wang

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  1. Fang Dong
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  2. Jian-Quan Liu
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  3. Xiang-Shan Wang
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Correspondence to Xiang-Shan Wang.

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Dong, F., Liu, JQ. & Wang, XS. An efficient synthesis of biaryl diamides via Ullmann coupling reaction catalyzed by CuI in the presence of Cs2CO3 and TBAB. Res Chem Intermed 44, 5271–5283 (2018). https://doi.org/10.1007/s11164-018-3422-0

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