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One-pot synthesis of five substituted tetrahydropyridines using nano-Al2O3/BF3/Fe3O4 as a highly efficient nano-catalyst

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Abstract

Nano-Al2O3/BF3/Fe3O4 was synthesized as an efficient and reusable catalyst. The synthesized magnetic catalyst has been characterized by various methods such as FT-IR, FESEM, TGA, TEM, VSM, XRF, XRD and BET. This catalyst does not need special precautions for preparation, handling or storage, and it can be stored at an ambient temperature for months without losing its catalytic activity. Five-substituted tetrahydropyridines and their derivatives have an interesting class of pharmaceutical activities. Thus, the nano-Al2O3/BF3/Fe3O4 catalyst was used to prepare five-substituted tetrahydropyridines by one-pot multicomponent reactions of aromatic aldehydes, anilines and β-keto-esters under solvent free conditions. The structure of products were studied by Fourier transform spectroscopy and nuclear magnetic resonance. The present protocol has notable advantages of easy purification, clean and convenient procedure and high yields for isolated products. In addition, this catalyst could be recycled several times without reduction in its admirable activity.

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Acknowledgements

The Research Council of Yazd University is gratefully acknowledged for financial support of this work.

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  1. Department of Chemistry, College of Science, Yazd University, P.O. Box 89195-741, Yazd, Iran

    Elaheh Babaei & Bi Bi Fatemeh Mirjalili

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  1. Elaheh Babaei
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  2. Bi Bi Fatemeh Mirjalili
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Correspondence to Bi Bi Fatemeh Mirjalili.

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Babaei, E., Mirjalili, B.B.F. One-pot synthesis of five substituted tetrahydropyridines using nano-Al2O3/BF3/Fe3O4 as a highly efficient nano-catalyst. Res Chem Intermed 44, 3493–3505 (2018). https://doi.org/10.1007/s11164-018-3320-5

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