Research on Chemical Intermediates

, Volume 44, Issue 5, pp 3493–3505 | Cite as

One-pot synthesis of five substituted tetrahydropyridines using nano-Al2O3/BF3/Fe3O4 as a highly efficient nano-catalyst

  • Elaheh Babaei
  • Bi Bi Fatemeh Mirjalili


Nano-Al2O3/BF3/Fe3O4 was synthesized as an efficient and reusable catalyst. The synthesized magnetic catalyst has been characterized by various methods such as FT-IR, FESEM, TGA, TEM, VSM, XRF, XRD and BET. This catalyst does not need special precautions for preparation, handling or storage, and it can be stored at an ambient temperature for months without losing its catalytic activity. Five-substituted tetrahydropyridines and their derivatives have an interesting class of pharmaceutical activities. Thus, the nano-Al2O3/BF3/Fe3O4 catalyst was used to prepare five-substituted tetrahydropyridines by one-pot multicomponent reactions of aromatic aldehydes, anilines and β-keto-esters under solvent free conditions. The structure of products were studied by Fourier transform spectroscopy and nuclear magnetic resonance. The present protocol has notable advantages of easy purification, clean and convenient procedure and high yields for isolated products. In addition, this catalyst could be recycled several times without reduction in its admirable activity.

Graphical Abstract


Tetrahydropyridine Nano-Al2O3/BF3/Fe3O4 Nano-catalyst Supported Lewis acid Magnetic catalyst 



The Research Council of Yazd University is gratefully acknowledged for financial support of this work.

Supplementary material

11164_2018_3320_MOESM1_ESM.docx (4.3 mb)
Supplementary material 1 (DOCX 4414 kb)


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Copyright information

© Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Chemistry, College of ScienceYazd UniversityYazdIran

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