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Glucose-containing imidazolium salt-catalyzed cross-aldol reaction of isatins and unactivated ketones

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Abstract

Ketone–ketone cross-aldol reaction of isatins and unactivated ketones was catalyzed by glucose-containing imidazolium salt β-1-imidazole-2,3,4,6-tetra-o-hydroxy-d-glucopyranosyl bromide in neutral condition to generate 3-alkyl-3-hydroxyindolin-2-ones in excellent yield.

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Acknowledgements

We are grateful to the foundation of the Priority Academic Program Development of Jiangsu Higher Education Institutions, Major Project of Natural Science Research of University in Jiangsu (nos. 14KJA430003, 15KJA180002), and Aid project for PhD faculties in Jiangsu Normal University (17XLR023), for financial support.

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Author notes

  1. Yu Wan and Rui Yuan contributed equally to this work.

Authors and Affiliations

  1. School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou, 221116, People’s Republic of China

    Hao Cui, Xiao-xiao Zhang, Ming-qi Li, Jiang-biao Xu, Peng-fei Dou, Long-yan Zhang & Hui Wu

  2. Key Laboratory of Biotechnology on Medical Plant of Jiangsu Province, Jiangsu Normal University, Xuzhou, 221116, People’s Republic of China

    Yu Wan, Rui Yuan & Hui Wu

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  1. Yu Wan
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  2. Rui Yuan
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  5. Ming-qi Li
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  9. Hui Wu
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Correspondence to Hui Wu.

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Wan, Y., Yuan, R., Cui, H. et al. Glucose-containing imidazolium salt-catalyzed cross-aldol reaction of isatins and unactivated ketones. Res Chem Intermed 44, 2561–2570 (2018). https://doi.org/10.1007/s11164-017-3246-3

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