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Montmorillonite K10: an effective catalyst for synthesis of 2-aminothiazoles

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Abstract

An efficient one-pot synthesis of 2-aminothiazoles from methylcarbonyl and thiourea has been developed using montmorillonite-K10 as a catalyst at 80 °C in DMSO medium. A plausible mechanism is proposed in which α-iodomethylcarbonyls are formed via methylcarbonyls as raw material using iodine as iodination reagent.

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Acknowledgment

We gratefully acknowledge the financial support from the Research Council of the University of Kashan for supporting this work by Grant No. 256722/III.

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Authors and Affiliations

  1. Department of Organic Chemistry, University of Kashan, P.O. Box 87317-51167, Kashan, Iran

    Javad Safari & Masoud Sadeghi

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  1. Javad Safari
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  2. Masoud Sadeghi
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Correspondence to Javad Safari.

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Safari, J., Sadeghi, M. Montmorillonite K10: an effective catalyst for synthesis of 2-aminothiazoles. Res Chem Intermed 42, 8175–8183 (2016). https://doi.org/10.1007/s11164-016-2587-7

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  • DOI: https://doi.org/10.1007/s11164-016-2587-7

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