Research on Chemical Intermediates

, Volume 42, Issue 9, pp 7153–7168 | Cite as

Design, synthesis, and antiviral activity of novel purine derivatives containing 1,4-pentadien-3-one moiety

  • Fang Wu
  • Pei Li
  • Deyu Hu
  • Baoan Song


A series of novel purine derivatives containing 1,4-pentadien-3-one moiety were designed and synthesized. The optimal conditions for the synthesis of the target compounds E 1 E 25 were as follows: solvent, DMF; catalyst, KOH; temperature, 40 °C; time, 2 h; and molar equivalent of A:D:Catalyst, 1:0.8:1.2. Antiviral bioassays indicated that compounds E 1 , E 3 , E 5 , E 7 , E 18 , and E 19 showed excellent protection activities, with EC50 values of 188.9, 194.6, 125.2, 134.1, 137.8, and 195.4 µg/mL, respectively, which were better than that of Ningnanmycin (271.2 μg/mL). To the best of our knowledge, this study is the first report on the design, synthesis, and antiviral activity of novel purine derivatives containing 1,4-pentadien-3-one moiety.


Purine 1,4-Pentadien-3-one Synthesis Antiviral activity 



We gratefully acknowledge support from the National Natural Science Foundation of China (Nos. 21132003 and 21362004).

Supplementary material

11164_2016_2524_MOESM1_ESM.docx (59 kb)
Supplementary material 1 (DOCX 58 kb)


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© Springer Science+Business Media Dordrecht 2016

Authors and Affiliations

  1. 1.State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine ChemicalsGuizhou UniversityGuiyangPeople’s Republic of China

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