Research on Chemical Intermediates

, Volume 42, Issue 6, pp 6013–6024 | Cite as

N-vinylcaprolactam-based microgels: synthesis, characterization and drug release applications

  • Bengi Özkahraman
  • Işıl Acar
  • Mehmet Koray Gök
  • Gamze Güçlü


In this study, N-vinylcaprolactam, metacrylic acid sodium salt and itaconic acid sodium salt-based copolymeric and terpolymeric microgels were synthesized by precipitation polymerization method with 2,2′-azobis(2-methylpropioamidine) dihydrochloride as initiator. Then these microgels were characterized by SEM technique, cloud points and colloidal properties determinations. Volume phase transitions of copolymeric and terpolymeric N-vinylcaprolactam-based microgels are determined at an interval of 32–37 °C. Rhodamine B (model drug) and Nadalol (beta-blocker drug) were used to investigate the drug loading and release behavior of microgels. It is concluded that model drug loading capacity and release amount changed with the presence and amount of itaconic acid sodium salt in the microgel structure. In addition, the maximum drug release amount of microgels was found to be 58 and 55 % for Rhodamine B and Nadolol, respectively. As a result, we can say that the microgels obtained in this study are suitable for drug delivery applications.


N-vinylcaprolactam Itaconic acid Methacrylic acid Microgel Rhodamine-B Nadolol Drug release 



This work is a part of the Ph.D. thesis titled “Usage of Polymeric Hydrogels and Microgels in Drug Release Applications”, prepared at Istanbul University, Institute of Science, and supported by the Research Fund of the Istanbul University, Project Number: 29693.


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Copyright information

© Springer Science+Business Media Dordrecht 2016

Authors and Affiliations

  • Bengi Özkahraman
    • 1
  • Işıl Acar
    • 2
  • Mehmet Koray Gök
    • 2
  • Gamze Güçlü
    • 2
  1. 1.Polymer Engineering Department, Faculty of EngineeringHitit UniversityÇorumTurkey
  2. 2.Department of Chemical Engineering, Faculty of EngineeringIstanbul UniversityAvcılar, IstanbulTurkey

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