Research on Chemical Intermediates

, Volume 42, Issue 3, pp 1583–1591 | Cite as

A straightforward route for covalently anchored pyridinium salt onto upper rim of c-methylcalix[4]resorcinarene with selective antibacterial activity against Gram-positive bacteria

  • Arash Mouradzadegun
  • Somayeh Elahi
  • Fatemeh Abadast
  • Hossein Motamedi


In this research, we report a straightforward route for the synthesis of a cationic supramolecular structure via covalently anchoring an ionic liquid-containing pyridinium moiety onto c-methylcalix[4]resorcinarene. Antibacterial activity of the new functionalized c-methylcalix[4]resorcinarene was evaluated against Gram-positive and Gram-negative bacteria. Surprisingly, this compound exhibited a selective antibacterial effect on Gram-positive bacteria, which is very important from the industrial and medicinal point of view. These preliminary results are attractive for the development of a new antibacterial agent.

Graphical Abstract


Functionalized c-methylcalix[4]resorcinarene Ionic liquid Supramolecular chemistry Bioorganic chemistry Selective antibacterial activity 



This work was supported by the Research Council at the Shahid Chamran University.

Supplementary material

11164_2015_2104_MOESM1_ESM.doc (1.1 mb)
Supplementary material 1 (DOC 1157 kb)


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Copyright information

© Springer Science+Business Media Dordrecht 2015

Authors and Affiliations

  • Arash Mouradzadegun
    • 1
  • Somayeh Elahi
    • 1
  • Fatemeh Abadast
    • 1
  • Hossein Motamedi
    • 2
  1. 1.Department of Chemistry, Faculty of SciencesShahid Chamran UniversityAhvazIran
  2. 2.Department of Biology, Faculty of SciencesShahid Chamran UniversityAhvazIran

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