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Research on Chemical Intermediates

, Volume 42, Issue 2, pp 1017–1028 | Cite as

One-pot catalyst-free synthesis of 3-heterocyclic coumarins

  • Shaoliang Jiang
  • Jianrong Gao
  • Liang Han
Article

Abstract

3-Heterocyclic coumarins were prepared in one-pot three-component reaction without catalyst. The mixture of salicylaldehydes, ethyl cyanoacetate, and o-aminophenols or o-phenylenediamines in refluxing n-butanol gave title compounds with good yields and high purity. Short reaction time, mild reaction condition, simple workup, and less waste are significant advantages of the presented method.

Keywords

3-Heterocyclic coumarin Catalyst free One-pot synthesis Salicylaldehyde 

Notes

Acknowledgments

The authors gratefully acknowledge the Natural Science Foundation of Zhejiang Province (no. LY12B03006) and National Natural Science Foundation of China (21406202) for funding.

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Copyright information

© Springer Science+Business Media Dordrecht 2015

Authors and Affiliations

  1. 1.College of Pharmaceutical ScienceZhejiang University of TechnologyHangzhouChina
  2. 2.College of Chemical EngineeringZhejiang University of TechnologyHangzhouChina

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