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One-pot catalyst-free synthesis of 3-heterocyclic coumarins

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Abstract

3-Heterocyclic coumarins were prepared in one-pot three-component reaction without catalyst. The mixture of salicylaldehydes, ethyl cyanoacetate, and o-aminophenols or o-phenylenediamines in refluxing n-butanol gave title compounds with good yields and high purity. Short reaction time, mild reaction condition, simple workup, and less waste are significant advantages of the presented method.

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Acknowledgments

The authors gratefully acknowledge the Natural Science Foundation of Zhejiang Province (no. LY12B03006) and National Natural Science Foundation of China (21406202) for funding.

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Authors and Affiliations

  1. College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, China

    Shaoliang Jiang

  2. College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, 310014, China

    Jianrong Gao & Liang Han

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  1. Shaoliang Jiang
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  2. Jianrong Gao
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  3. Liang Han
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Correspondence to Liang Han.

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Jiang, S., Gao, J. & Han, L. One-pot catalyst-free synthesis of 3-heterocyclic coumarins. Res Chem Intermed 42, 1017–1028 (2016). https://doi.org/10.1007/s11164-015-2070-x

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