Research on Chemical Intermediates

, Volume 42, Issue 2, pp 977–986 | Cite as

One-pot synthesis of ferrocenyl-pyrimidones using a recyclable molibdosilicic H4SiMo12O40 heteropolyacid

  • Jorge L. Jios
  • Nils Metzler-Nolte
  • Patricia G. Vázquez
  • Gustavo P. Romanelli


A series of ferrocene-containing dihydropyrimidines (DHPs) were prepared by the one-pot Biginelli reaction of formylferrocene, 1,3-dicarbonyl component and urea/thiourea. The reaction was catalyzed by a commercial Keggin heteropolyacid (H4SiMo12O40) as a safe, clean and recyclable catalyst. Three different synthetic protocols were examined in order to improve the yields of the reaction and to elucidate its mechanism. Intermediates of the competitive Knoevenagel reaction were also isolated. The methodology is operationally simple and provides access to highly substituted dihydropyrimidines containing ferrocene in very good yields. The catalyst can be used and recycled without appreciable loss of the catalytic activity.


Ferrocene Dihydropyrimidinones Biginelli reaction Recyclable Keggin heteropolyacid One-pot reaction 



We thank Universidad Nacional de La Plata, CONICET and ANPCyT for financial support. GR is member of CONICET. J.L.J. acknowledges the Deutscher Akademischer Austauschdienst, Germany (DAAD), for a scholarship.


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Copyright information

© Springer Science+Business Media Dordrecht 2015

Authors and Affiliations

  1. 1.Unidad Laseisic-Plapimu (UNLP-CIC), Departamento de Química, Facultad de Ciencias ExactasUniversidad Nacional de La PlataLa PlataArgentina
  2. 2.Lehrstuhl für Anorganische Chemie I—Bioanorganische Chemie, Fakultät für Chemie und BiochemieRuhr-Universität BochumBochumGermany
  3. 3.Centro de Investigación y Desarrollo en Ciencias Aplicadas “Dr. Jorge J. Ronco” (CINDECA-CCT-CONICET)Universidad Nacional de La PlataLa PlataArgentina

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