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Research on Chemical Intermediates

, Volume 41, Issue 12, pp 9703–9713 | Cite as

One-pot multicomponent synthesis of novel thiazolylhydrazone derivatives and their antimicrobial activity

  • G. Rajitha
  • V. Ravibabu
  • G. Ramesh
  • B. Rajitha
  • R. Jobina
  • B. Siddhardha
  • S. Vijaya Laxmi
Article

Abstract

A series of novel thiazolylhydrazone derivatives (4af, 6af) were synthesized via one-pot multicomponent condensation of 1,3-indandione (1), thiosemicarbazide (2) and 3-(2-bromoacetyl)-2H-chromen-2-ones (3af)/2-bromo-1-(4-substituted-phenyl)ethanone (5af). All the synthesized compounds were characterized by spectral and elemental analyses. All the synthesized compounds were evaluated for their in vitro antimicrobial activity. Antibacterial activity results revealed that compound 6d, possessing 4-methylphenyl on thiazole ring, has shown equipotent activity against K. pneumoniae (ZOI 22 mm, MIC 50 µg/ml) on comparing with the standard drug Streptomycin. Compounds 4af, 6a, 6b, and 6d against P. aeruginosa and compounds (4ad) against S. pyogenes have shown promising antibacterial activity with ZOI ranging from 14 to 17 mm. Antifungal activity results revealed that, compound 6d has shown maximum zone of inhibition against four fungal strains C. albicans, C. glabrata, A. niger, and A. parasiticus with ZOI 19, 16, 20, and 20 mm, respectively, on comparing with the standard drug clotrimazole.

Keywords

1,3-Indandione Antimicrobial activity Thiazolylhydrazones 3-(2-Bromoacetyl)-2H-chromen-2-ones 

Notes

Acknowledgments

The authors thank the Director, National Institute of Technology, Warangal for providing facilities. The authors RG and RV are thankful to University Grant Commission (UGC) New Delhi, for senior research fellowship.

Supplementary material

11164_2015_1959_MOESM1_ESM.docx (5 mb)
Supplementary material 1 (DOCX 5141 kb)

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Copyright information

© Springer Science+Business Media Dordrecht 2015

Authors and Affiliations

  • G. Rajitha
    • 1
  • V. Ravibabu
    • 1
  • G. Ramesh
    • 1
  • B. Rajitha
    • 1
  • R. Jobina
    • 2
  • B. Siddhardha
    • 2
  • S. Vijaya Laxmi
    • 3
  1. 1.Department of ChemistryNational Institute of TechnologyWarangalIndia
  2. 2.Centre for Microbiology, School of Life SciencesPondicherry UniversityPuducherryIndia
  3. 3.Department of ChemistryK L UniversityGunturIndia

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