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Research on Chemical Intermediates

, Volume 41, Issue 11, pp 8965–8974 | Cite as

Synthesis, photoluminescent, antibacterial activities and theoretical studies of three novel coumarin and dihydropyran derivatives containing a triphenylamine group

  • Xin Shi
  • Chang-wei Lv
  • Jing Li
  • Zheng Hou
  • Xiao-hui Yang
  • Zi-dan Zhang
  • Xiao-xing Luo
  • Zhi Yuan
  • Ming-kai Li
Article

Abstract

Three new coumarin and dihydropyran derivatives (1–3) have been synthesized and their fluorescence behaviors in dichloromethane solutions were observed. The molecular structures of two representative compounds, 2 and 3, were confirmed by single crystal X-ray diffraction study. The three synthesized compounds were evaluated for their antibacterial activities against Staphylococcus aureus (S. aureus ATCC 29213), methicillin-resistant S. aureus (MRSA XJ 75302), vancomycin-intermediate S. aureus (Mu50 ATCC 700699), and USA 300 (Los Angeles County clone) in vitro by observing the minimum inhibitory concentration.

Keywords

Coumarin Dihydropyran Staphylococcus aureus Minimum inhibitory concentration 

Notes

Acknowledgments

This work was supported by grants from the National Natural Science Foundation of China (Nos. 81001460 and 81273555) the Innovation plan of science and technology of Shaanxi Province (2014KTCL03-03) and the Development plan of science and technology research of Shaanxi Province (2012K14-01-04). The authors thank the High Performance Computing Center of Tianjin University and Prof. Xue-hao He for the services provided.

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Copyright information

© Springer Science+Business Media Dordrecht 2015

Authors and Affiliations

  • Xin Shi
    • 1
  • Chang-wei Lv
    • 2
  • Jing Li
    • 3
  • Zheng Hou
    • 1
  • Xiao-hui Yang
    • 3
  • Zi-dan Zhang
    • 4
  • Xiao-xing Luo
    • 1
  • Zhi Yuan
    • 2
  • Ming-kai Li
    • 1
  1. 1.Department of Pharmacology, School of PharmacyFourth Military Medical UniversityXi’anChina
  2. 2.Department of Orthopaedics, Xijing HospitalFourth Military Medical UniversityXi’anChina
  3. 3.School of Chemistry and Chemical EngineeringXi’an UniversityXi’anChina
  4. 4.Department of Physics, School of ScienceTianjin UniversityTianjinChina

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