Research on Chemical Intermediates

, Volume 41, Issue 11, pp 8699–8711 | Cite as

Synthesis and biological evaluation of thiazolo and imidazo N-(4-nitrophenyl)-7-methyl-5-aryl-pyrimidine-6 carboxamide derivatives

  • Priyanka Dhiman
  • Neelam Malik
  • Prabhakar K. Verma
  • Anurag Khatkar


Two new series of thiazolo and imidazo N-(4-nitrophenyl)-7-methyl-5-aryl-pyrimidine-6 carboxamide derivatives were synthesized. All the synthesized compounds were evaluated for their antimicrobial activity against Gram-positive bacteria: Staphylococcus aureus MTCC 3160, Bacillus subtilis MTCC 441, Gram-negative bacterium: Escherichia coli MTCC 443 and antifungal activity against Candida albicans MTCC 227 and Aspergillus niger MTCC 281 and free radical scavenging activity. Compound 7e was found the most active antimicrobial comparable to standards taken. Compounds 7a, 7c, 9a, and 9d also showed significant antibacterial and antifungal activity. Further, compounds 7f, 9d, and 9h showed significant antioxidant activity with IC50 comparable with the standard compound. The synthesized compounds were confirmed for their structure by means of various spectrometric techniques like IR, 1H NMR, mass, and elemental analysis.


Bigenelli-pyrimidine Dihydropyrimidine Antibacterial Antifungal Antioxidant 


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Copyright information

© Springer Science+Business Media Dordrecht 2015

Authors and Affiliations

  • Priyanka Dhiman
    • 1
  • Neelam Malik
    • 1
  • Prabhakar K. Verma
    • 1
  • Anurag Khatkar
    • 1
  1. 1.Medicinal Chemistry Division, Faculty of Pharmaceutical SciencesM.D. UniversityRohtakIndia

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