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Research on Chemical Intermediates

, Volume 41, Issue 6, pp 3709–3718 | Cite as

Pentafluorophenylammonium triflate as a suitable and effective metal-free catalyst for the synthesis of quinazoline derivatives via one-pot multicomponent method

  • Samad Khaksar
  • Milad Gholami
Article

Abstract

A simple and facile synthesis of highly functionalized quinazoline derivatives has been successfully developed by treatment of aldehydes, ammonium acetate, and 2-aminoaryl ketones or isatoic anhydride under reflux conditions in the presence of a pentafluorophenylammonium triflate (PFPAT) organocatalyst. These catalytic condensation reactions represent green chemical processes, while the PFPAT organocatalyst is air-stable, cost-effective, easy to handle, and easily removed from the reaction mixtures.

Keywords

Organocatalyst Metal-free Quinazoline PFPAT 

Notes

Acknowledgment

This research is supported by the Islamic Azad University, Ayatollah Amoli Branch.

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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  1. 1.Chemistry DepartmentIslamic Azad UniversityAmolIran

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