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Research on Chemical Intermediates

, Volume 41, Issue 6, pp 3543–3561 | Cite as

Synthesis of fused 1,2,4-triazines as potential antimicrobial and antitumor agents

  • Mohamed Abd El-Moneim
  • J. A. Hasanen
  • I. M. El-Deen
  • W. Abd El-Fattah
Article

Abstract

5-Benzylidene-3-(p-chlorophenyl)-2-aminothiocarbonyl-1,2,4-triazine (2) was prepared via condensation of oxazolinone (1) with thiosemicarbazide. Fused 1,2,4-triazine derivatives (3, 4 and 9) were synthesized from the reaction of compound 2 with ω-bromomethyl aryl ketones, ethyl chloroacetate, and acetic anhydride. Treatment of 4 with acetic anhydride and aromatic aldehydes yielded the corresponding acetyl, diacetyl derivatives (6 and 7) and 7-benzylidene-5-(p-chlorophenyl)-4-thioxo-3-arylidene-1,2,4-triazino [2,1-a]-1,2,4-triazine-1,8-diones (8). The electron impact mass spectra of both the above series of compounds have also been recorded and their fragmentation pattern is discussed. All synthesized fused 1,2,4-triazine derivatives were primary in vitro screened for their antimicrobial and antitumor activity.

Keywords

Fused 1,2,4-triazine Spectral studies Synthesis Biological activity 

Notes

Acknowledgment

The authors acknowledge that the regional center for mycology and biotechnology that has contributed greatly to this study.

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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Mohamed Abd El-Moneim
    • 1
  • J. A. Hasanen
    • 2
  • I. M. El-Deen
    • 1
  • W. Abd El-Fattah
    • 1
  1. 1.Chemistry Department, Faculty of SciencePort-Said UniversityPort SaidEgypt
  2. 2.Chemistry Department, Faculty of ScienceSuez Canal UniversityIsmailiaEgypt

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