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Efficient copper(I)-catalyzed, microwave-assisted, one-pot synthesis of 3,4-diaryl isoquinolines

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Abstract

An efficient copper-catalyzed, microwave-assisted, one-pot reaction has been developed for synthesis of 3,4-diaryl isoquinolines. The reaction was performed in two steps via a CuI/2,2′-biimidazole-catalyzed tandem process from N-tert-butyl-o-iodobenzaldimine and a terminal aryl alkyne, followed by addition of an aryl iodide. A variety of 3,4-diaryl isoquinolines have been obtained in moderate to good yields.

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Acknowledgments

This work was supported by the Program for Excellent Talents in Guangdong Ocean University (Grant No. 0912118).

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Authors and Affiliations

  1. Department of Chemistry, College of Science, Guangdong Ocean University, Zhanjiang, 524088, China

    Zhang Hu, Si-Dong Li & Lei Yang

  2. College of Pharmaceutical Science, Zhejiang University, Hangzhou, 310058, China

    Li-Li Ou

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  1. Zhang Hu
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  2. Li-Li Ou
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  3. Si-Dong Li
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  4. Lei Yang
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Correspondence to Zhang Hu.

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Hu, Z., Ou, LL., Li, SD. et al. Efficient copper(I)-catalyzed, microwave-assisted, one-pot synthesis of 3,4-diaryl isoquinolines. Res Chem Intermed 41, 3461–3469 (2015). https://doi.org/10.1007/s11164-013-1462-z

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  • DOI: https://doi.org/10.1007/s11164-013-1462-z

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