Efficient copper(I)-catalyzed, microwave-assisted, one-pot synthesis of 3,4-diaryl isoquinolines
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An efficient copper-catalyzed, microwave-assisted, one-pot reaction has been developed for synthesis of 3,4-diaryl isoquinolines. The reaction was performed in two steps via a CuI/2,2′-biimidazole-catalyzed tandem process from N-tert-butyl-o-iodobenzaldimine and a terminal aryl alkyne, followed by addition of an aryl iodide. A variety of 3,4-diaryl isoquinolines have been obtained in moderate to good yields.
KeywordsIsoquinolines Copper-catalyzed One-pot synthesis Microwave irradiation
This work was supported by the Program for Excellent Talents in Guangdong Ocean University (Grant No. 0912118).
- 1.R.S. Gupta, V.P. Dixit, M.P. Dobhal, Fitoterapia 61, 67 (1990)Google Scholar