Research on Chemical Intermediates

, Volume 41, Issue 2, pp 1203–1211 | Cite as

Synthesis of 2-substituted 7-methylpyrimido[4,5-d]pyrimidin-4(3H)-ones catalyzed by heteropolyacids

  • Zheng Dong Fang
  • Di Fang
  • Yu Yuan Tan


A series of 2-substituted 7-methylpyrimido[4,5-d]pyrimidin-4(3H)-ones have been synthesized in good yields by reaction of 4-amino-2-methylpyrimidine-5-carboxamide with aromatic aldehydes in the presence of three heteropolyacids, H3PMo12O40, H3PW12O40, and H5PV2Mo10O40. In this reaction the catalytic activity of H3PMo12O40 and H3PW12O40 was lower than that of H5PV2Mo10O40. All the synthesized compounds were characterized on the basis of elemental analysis and spectral data (IR, 1H NMR, 13C NMR, and ESIMS). It is an effective way of synthesis of 2-substituted 7-methylpyrimido[4,5-d]pyrimidin-4(3H)-one derivatives, with the advantages of mild reaction conditions, simple operation, and good yields.


Pyrimido[4,5-d]pyrimidin-4(3H)-one Heteropolyacids Synthesis Catalyst 


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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  1. 1.College of Chemistry and Environmental EngineeringHubei Normal UniversityHuangshiPeople’s Republic of China
  2. 2.College of Art and Science of Hubei Normal UniversityHuangshiPeople’s Republic of China

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