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Research on Chemical Intermediates

, Volume 40, Issue 5, pp 2083–2090 | Cite as

Facile microwave-assisted synthesis of substituted benzofuran derivatives

  • Junqiang Liu
  • Chenggen Mi
  • Xuemei Tang
  • Yuan Cao
  • Zicheng Li
  • Wencai Huang
Article

Abstract

A series of benzofuran derivatives have been synthesized by use of a microwave-assisted process. Substituted or unsubstituted ο-hydroxyacetophenone and salicylaldehyde reacted with ethyl bromoacetate, ω-bromoacetophenone, or chloroacetone under the action of potassium carbonate in DMF to yield substituted benzofuran derivatives. Compared with conventional heating, this microwave-assisted synthetic process has the advantages of more convenient operation, shorter reaction time, and higher yield.

Keywords

Microwave-assisted reaction Benzofuran ο-Hydroxyacetophenone Salicylaldehyde 

Notes

Acknowledgments

We thank the Analytical and Testing Center of Sichuan University for NMR and MS spectral measurements.

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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Junqiang Liu
    • 1
  • Chenggen Mi
    • 1
  • Xuemei Tang
    • 1
  • Yuan Cao
    • 1
  • Zicheng Li
    • 1
  • Wencai Huang
    • 1
  1. 1.Department of Pharmaceutical and Bioengineering, School of Chemical EngineeringSichuan UniversityChengduPeople’s Republic of China

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