Research on Chemical Intermediates

, Volume 40, Issue 5, pp 1989–1995 | Cite as

One-pot, four-component synthesis of 2H-indazolo[2,1-b]phthalazine-triones catalyzed by cellulose-SO3H as a reusable heterogeneous and efficient catalyst



A practical and green method for the synthesis of 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione derivatives using cellulose-SO3H as a solid acidic catalyst for the four-component condensation reaction of hydrazinium hydroxide, phthalic anhydride, dimedone, and aromatic aldehydes under thermal solvent-free conditions is described. Cellulose-SO3H as a recyclable green chemical compound has been demonstrated as a new catalyst for the synthesis of this class of compounds.


Cellulose-SO3Four-component reaction 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione Solvent-free Heterogeneous catalyst 



We are thankgrateful to the University of Sistan and Baluchestan Research Council for the partial support of this research.


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© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  1. 1.Department of Chemistry, Faculty of SciencesUniversity of Sistan and BaluchestanZahedanIran

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