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Research on Chemical Intermediates

, Volume 40, Issue 5, pp 1851–1866 | Cite as

Regioselective synthesis of novel 2-chloroquinoline derivatives of 1,4-dihydropyridines

  • K. Rajesh
  • P. Iniyavan
  • S. Sarveswari
  • V. Vijayakumar
Article

Abstract

Highly regioselective reaction of some substituted 2,4-dichloroquinolines with symmetrical 1,4-dihydropyridines, leading to novel quinoline derivatives of DHPs, has been achieved in the presence of powdered K2CO3, as a mild and efficient base, at moderate temperature. All the synthesized compounds were characterized by use of IR, NMR, and mass spectral data.

Keywords

Hantzsch reaction 1,4-DHPs 2,4-Dichloroquinolines Regioselectivity 

Notes

Acknowledgments

We are grateful for financial support from the Department of Science and Technology, Government of India (grant no. SR/FTP/CS-108/2006) and VIT University, Vellore, for providing research facilities.

Supplementary material

11164_2013_1085_MOESM1_ESM.doc (10 mb)
Supplementary material 1 (DOC 10231 kb)

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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • K. Rajesh
    • 1
    • 2
  • P. Iniyavan
    • 1
  • S. Sarveswari
    • 1
  • V. Vijayakumar
    • 1
  1. 1.Centre for Organic and Medicinal ChemistryVIT UniversityVelloreIndia
  2. 2.Department of ChemistryMS Ramaiah Institute of TechnologyBangaloreIndia

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