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Regioselective synthesis of novel 2-chloroquinoline derivatives of 1,4-dihydropyridines

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Abstract

Highly regioselective reaction of some substituted 2,4-dichloroquinolines with symmetrical 1,4-dihydropyridines, leading to novel quinoline derivatives of DHPs, has been achieved in the presence of powdered K2CO3, as a mild and efficient base, at moderate temperature. All the synthesized compounds were characterized by use of IR, NMR, and mass spectral data.

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Acknowledgments

We are grateful for financial support from the Department of Science and Technology, Government of India (grant no. SR/FTP/CS-108/2006) and VIT University, Vellore, for providing research facilities.

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Authors and Affiliations

  1. Centre for Organic and Medicinal Chemistry, VIT University, Vellore, 632 014, Tamil Nadu, India

    K. Rajesh, P. Iniyavan, S. Sarveswari & V. Vijayakumar

  2. Department of Chemistry, MS Ramaiah Institute of Technology, Bangalore, 560054, Karnataka, India

    K. Rajesh

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  1. K. Rajesh
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  2. P. Iniyavan
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  4. V. Vijayakumar
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Correspondence to V. Vijayakumar.

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Rajesh, K., Iniyavan, P., Sarveswari, S. et al. Regioselective synthesis of novel 2-chloroquinoline derivatives of 1,4-dihydropyridines. Res Chem Intermed 40, 1851–1866 (2014). https://doi.org/10.1007/s11164-013-1085-4

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