Research on Chemical Intermediates

, Volume 39, Issue 9, pp 4259–4267 | Cite as

Regioselective synthesis and biological evaluation of novel bis(2-chloroquinolines)

  • K. Rajesh
  • B. Palakshi Reddy
  • S. Sarveswari
  • V. Vijayakumar


Reaction of substituted 2,4-dichloroquinolines with bisphenol A in the presence of K2CO3 leads to novel bis(2-chloroquinolines) with high regioselectivity. All the synthesized compounds were characterized by use of spectral data. Preliminary evaluation of in-vitro antibacterial activity against a variety of Gram-positive and Gram-negative organisms was also conducted.


Bis(2-chloroquinolines) 2,4-Dichloroquinolines Bisphenol A Anti-bacterial activity 



We are grateful for financial support from the Department of Science and Technology, Government of India (grant no. SR/FTP/CS-108/2006) and to VIT University, Vellore, for providing research facilities.

Supplementary material

11164_2012_942_MOESM1_ESM.doc (6.5 mb)
Supplementary material 1 (DOC 6706 kb)


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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • K. Rajesh
    • 1
  • B. Palakshi Reddy
    • 1
  • S. Sarveswari
    • 1
  • V. Vijayakumar
    • 1
  1. 1.Centre for Organic and Medicinal ChemistryVIT UniversityVelloreIndia

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