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Regioselective synthesis and biological evaluation of novel bis(2-chloroquinolines)

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Abstract

Reaction of substituted 2,4-dichloroquinolines with bisphenol A in the presence of K2CO3 leads to novel bis(2-chloroquinolines) with high regioselectivity. All the synthesized compounds were characterized by use of spectral data. Preliminary evaluation of in-vitro antibacterial activity against a variety of Gram-positive and Gram-negative organisms was also conducted.

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Acknowledgments

We are grateful for financial support from the Department of Science and Technology, Government of India (grant no. SR/FTP/CS-108/2006) and to VIT University, Vellore, for providing research facilities.

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Authors and Affiliations

  1. Centre for Organic and Medicinal Chemistry, VIT University, Vellore, 632 014, Tamil Nadu, India

    K. Rajesh, B. Palakshi Reddy, S. Sarveswari & V. Vijayakumar

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  1. K. Rajesh
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  2. B. Palakshi Reddy
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  3. S. Sarveswari
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Correspondence to V. Vijayakumar.

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Rajesh, K., Palakshi Reddy, B., Sarveswari, S. et al. Regioselective synthesis and biological evaluation of novel bis(2-chloroquinolines). Res Chem Intermed 39, 4259–4267 (2013). https://doi.org/10.1007/s11164-012-0942-x

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