Research on Chemical Intermediates

, Volume 39, Issue 9, pp 4121–4125 | Cite as

One-pot synthesis of 6-bromo-4,4-dimethylthiochroman

  • Shaodong Zhou
  • Zutai Liao
  • Jixin Yuan
  • Chao Qian
  • Xinzhi Chen


One-pot synthesis of 6-bromo-4,4-dimethylthiochroman from bromobenzene is reported. The crucial connection between the three steps is that the byproducts in the first two steps are used as the catalyst in the third step. Compared with the previous route, this approach is of low consumption and low pollution.


One-pot synthesis 6-Bromo-4,4-dimethylthiochroman Byproduct utilization Heterocyclic 1-Bromo-3-methylbut-2-ene 



The authors gratefully acknowledge funding support by grants from the National Natural Science Foundation of China (no. 21076183) and from the Science and Technology Innovation Team of Zhejiang Province (no. 2009R50002).


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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Shaodong Zhou
    • 1
  • Zutai Liao
    • 2
  • Jixin Yuan
    • 2
  • Chao Qian
    • 1
  • Xinzhi Chen
    • 1
  1. 1.State Key Laboratory of Chemical Engineering, Department of Chemical and Biological EngineeringZhejiang UniversityHangzhouChina
  2. 2.Jiangxi Renming Pharmaceutical Chemicals Ltd.JiujiangChina

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